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Nutrients 2017, 9(11), 1223;

Coffee Decreases the Risk of Endometrial Cancer: A Dose–Response Meta-Analysis of Prospective Cohort Studies

The Research Centre on Public Health, University Milano-Bicocca, via Pergolesi 33, 20900 Monza, Italy
Department of International Health, FHML, CAPHRI, Maastricht University, 6229 Maastricht, The Netherlands
Department of Epidemiology and Population Studies, Jagiellonian University Medical College, 31008 Krakow, Poland
Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy
Division of Medical Oncology, Department of Uro-Gynaecological Oncology, Istituto Nazionale Tumori ‘Fondazione G. Pascale’—IRCCS, 80131 Naples, Italy
Gynecological Oncology, National Cancer Institute—IRCCS, 33081 Aviano (PN), Italy
Department of Medical Oncology, National Cancer Institute—IRCCS, 33081 Aviano (PN), Italy
Author to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 27 October 2017 / Accepted: 3 November 2017 / Published: 9 November 2017
(This article belongs to the Special Issue Effects of Polyphenol-Rich Foods on Human Health)
Full-Text   |   PDF [888 KB, uploaded 21 November 2017]   |  


Aim: The aim of this study was to perform a comprehensive meta-analysis of the association between coffee consumption and risk of endometrial cancer. Methods: Eligible studies were identified by searching the PubMed and EMBASE databases. The dose–response relationship as well as the risk of endometrial cancer for the highest versus the lowest categories of coffee consumption were assessed. Subgroup analyses considering the menopausal and receptor statuses, the smoking status, and the BMI (Body Mass Index) were performed in order to identify potential confounders. Results: We identified a total of 12 studies eligible for meta-analysis. A dose–response meta-analysis showed a decreased risk of endometrial cancer. Moreover, a subgroup analysis indicated that coffee consumption is significantly associated with a decreased risk of postmenopausal cancer. Increasing coffee consumption by four cups per day was associated with a 20% reduction in endometrial cancer risk (relative risk (RR) 0.80; 95% confidence interval (CI) 0.72 to 0.89) and with a 24% reduction in postmenopausal cancer risk (RR 0.76; 95% CI 0.69 to 0.83). Conclusions: Our findings suggest that increased coffee consumption is associated with decreased risk of endometrial cancer, and this association is observed also for postmenopausal cancer. View Full-Text
Keywords: coffee; caffeine; postmenopausal; endometrial cancer; prospective cohort; meta-analysis coffee; caffeine; postmenopausal; endometrial cancer; prospective cohort; meta-analysis

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Lafranconi, A.; Micek, A.; Galvano, F.; Rossetti, S.; Del Pup, L.; Berretta, M.; Facchini, G. Coffee Decreases the Risk of Endometrial Cancer: A Dose–Response Meta-Analysis of Prospective Cohort Studies. Nutrients 2017, 9, 1223.

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