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Nutrients 2017, 9(11), 1217;

Pediatric Chronic Intestinal Failure in Italy: Report from the 2016 Survey on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP)

Artificial Nutrition Unit Bambino Gesù, Children’s Hospital, IRCCS, 00165 Rome, Italy
Gastroenterology Unit, G. Gaslini Institute for Maternal and Child Health, IRCCS, 16145 Genova, Italy
Department of Pediatrics, “Burlo Garofolo” Hospital, University of Trieste, IRCCS, 34137 Trieste, Italy
Division of Nutrition, Regina Margherita Children’s Hospital, 10126 Turin, Italy
Department of Gastroenterology and Nutrition Unit, Meyer Children’s Hospital, 50139 Florence, Italy
Department of Transalational Medical Science, Section of Pediatrics, University of Naples Federico II, 80138 Naples, Italy
Department of Paediatrics, Università Politecnica delle Marche, 60121 Ancona, Italy
Paediatric, Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, 24127 Bergamo, Italy
Department of Women’s and Children’s Health, University of Padua, 35122 Padua, Italy
Department of Clinical Science and Community Health, Neonatal Intensive Care Unit, Fondazione IRCSS Cà Granda Ospedale Maggiore Policlinico, University of Milan, 20122 Milan, Italy
Pediatrics Unit, Department of Women’s and Children’s Health, IRCCS Arcispedale Santa Maria Nuova, 42123 Reggio Emilia, Italy
Department of Biomedical Science and Human Oncology, Section of Neonatology and NICU, University of Bari, 70121 Bari, Italy
Department for the Treatment and Study of Pediatric Abdominal Diseases and Abdominal Transplantation, IRCCS ISMETT, 90127 Palermo, Italy
Department of Pathology, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Unit of Pediatrics, University of Foggia, 71122 Foggia, Italy
Pediatric Gastroenterology, Hepatology and Digestive Endoscopic Unit, University Hospital Umberto I, 00185 Rome, Italy
Unit of Pediatrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, 98122 Messina, Italy
Hepatology and Gastroenterology Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Santobono-Pausillipon” Children’s Hospital, 80138 Naples, Italy
Department of Medical and Surgical Neonatology, Bambino Gesù Children’s Hospital, 00165 Rome, Italy
Digestive Endoscopy and Surgery Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Department of Pediatric Surgery, “Spedali Civili” Children’s Hospital, 25123 Brescia, Italy
Pediatric Surgery Unit, Women’s and Children’s Health Department, University of Padua, 35122 Padua, Italy
Department of Pediatric Surgery, S. Orsola Malpighi Polyclinic, 40138 Bologna, Italy
Department of Abdominal Transplantation and Hepatobiliary and Pancreatic Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Author to whom correspondence should be addressed.
Received: 9 October 2017 / Revised: 25 October 2017 / Accepted: 27 October 2017 / Published: 5 November 2017
(This article belongs to the Special Issue Nutrition in Pediatric Gastroenterology: Selected Papers from SIGENP)
PDF [490 KB, uploaded 6 November 2017]


Background: Intestinal failure (IF) is the reduction in functioning gut mass below the minimal level necessary for adequate digestion and absorption of nutrients and fluids for weight maintenance in adults or for growth in children. There is a paucity of epidemiologic data on pediatric IF. The purpose of this study was to determine the prevalence, incidence, regional distribution and underlying diagnosis of pediatric chronic IF (CIF) requiring home parenteral nutrition (HPN) in Italy. Methods: Local investigators were selected in 19 Italian centers either of reference for pediatric HPN or having pediatric gastroenterologists or surgeons on staff and already collaborating with the Italian Society for Pediatric Gastroenterology, Hepatology and Nutrition with regard to IF. Data requested in this survey for children at home on Parenteral Nutrition (PN) on 1 December 2016 included patient initials, year of birth, gender, family’s place of residence and underlying diagnosis determining IF. Results: We recorded 145 CIF patients on HPN aged ≤19 years. The overall prevalence was 14.12/million inhabitants (95% CI: 9.20–18.93); the overall incidence was 1.41/million inhabitant years (95% CI: 0.53–2.20). Conclusion: Our survey provides new epidemiological data on pediatric CIF in Italy; these data may be quantitatively useful in developing IF care strategy plans in all developed countries. View Full-Text
Keywords: intestinal failure; home parenteral nutrition; children intestinal failure; home parenteral nutrition; children

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Diamanti, A.; Capriati, T.; Gandullia, P.; Di Leo, G.; Lezo, A.; Lacitignola, L.; Spagnuolo, M.I.; Gatti, S.; D’Antiga, L.; Verlato, G.; Roggero, P.; Amarri, S.; Baldassarre, M.E.; Cirillo, F.; Elia, D.; Boldrini, R.; Campanozzi, A.; Catassi, C.; Aloi, M.; Romano, C.; Candusso, M.; Cecchi, N.; Bellini, T.; Tyndall, E.; Fusaro, F.; Caldaro, T.; Alberti, D.; Gamba, P.; Lima, M.; Bagolan, P.; De Ville de Goyet, J.; Dall’Oglio, L.; Spada, M.; Grandi, F. Pediatric Chronic Intestinal Failure in Italy: Report from the 2016 Survey on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP). Nutrients 2017, 9, 1217.

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