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Isoflavones: Anti-Inflammatory Benefit and Possible Caveats

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China
Author to whom correspondence should be addressed.
Nutrients 2016, 8(6), 361;
Received: 26 February 2016 / Revised: 19 May 2016 / Accepted: 2 June 2016 / Published: 10 June 2016
(This article belongs to the Special Issue Flavonoids, Inflammation and Immune System)
PDF [983 KB, uploaded 10 June 2016]


Inflammation, a biological response of body tissues to harmful stimuli, is also known to be involved in a host of diseases, such as obesity, atherosclerosis, rheumatoid arthritis, and even cancer. Isoflavones are a class of flavonoids that exhibit antioxidant, anticancer, antimicrobial, and anti-inflammatory properties. Increasing evidence has highlighted the potential for isoflavones to prevent the chronic diseases in which inflammation plays a key role, though the underlying mechanisms remain unclear. Recently, some studies have raised concerns about isoflavones induced negative effects like carcinogenesis, thymic involution, and immunosuppression. Therefore, this review aims to summarize the anti-inflammatory effects of isoflavones, unravel the underlying mechanisms, and present the potential health risks. View Full-Text
Keywords: isoflavones; anti-inflammation; health risks; flavonoids isoflavones; anti-inflammation; health risks; flavonoids

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Yu, J.; Bi, X.; Yu, B.; Chen, D. Isoflavones: Anti-Inflammatory Benefit and Possible Caveats. Nutrients 2016, 8, 361.

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