Next Article in Journal
Isoflavones: Anti-Inflammatory Benefit and Possible Caveats
Next Article in Special Issue
Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity
Previous Article in Journal
Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer
Previous Article in Special Issue
Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells
Open AccessFeature PaperReview

Challenges in Analyzing the Biological Effects of Resveratrol

Department of Science and Environment, Roskilde University, Universitetsvej 1, Roskilde DK-4000, Denmark
Author to whom correspondence should be addressed.
Nutrients 2016, 8(6), 353;
Received: 29 March 2016 / Revised: 26 May 2016 / Accepted: 31 May 2016 / Published: 9 June 2016
(This article belongs to the Special Issue Selected Papers from Resveratrol Regional Meeting 2015)
The suggested health effects (e.g., disease prevention) of dietary bioactive compounds such as resveratrol are challenging to prove in comparison to man-made drugs developed for therapeutic purposes. Dietary bioactive compounds have multiple cellular targets and therefore have a variety of biological effects. Extrapolating the biological effects of dietary compounds from in vitro and in vivo animal experiments to humans may lead to over- or under-estimation of the effect and role of these compounds. The present paper will discuss a few of these challenges and suggest directions for future research. Questions we address include: (1) Is the combinatorial effect of resveratrol and other compounds real? (2) What are the real and relevant doses of resveratrol after administration? and (3) Is it possible to estimate the preventive effect of resveratrol by clinical trials using standard experimental designs? The examples concerning resveratrol taken from the scientific literature are mainly from 2010 and later. The challenges pointed out in this review are similar to most naturally occurring bioactive compounds. View Full-Text
Keywords: resveratrol; combinatory effect; complex mixtures; bioavailability; preventive human studies resveratrol; combinatory effect; complex mixtures; bioavailability; preventive human studies
Show Figures

Graphical abstract

MDPI and ACS Style

Erdogan, C.S.; Vang, O. Challenges in Analyzing the Biological Effects of Resveratrol. Nutrients 2016, 8, 353.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop