Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer
by
Can Liu 1,2,3, Longhai Dai 2, Yueping Liu 1,3,*, Long Rong 4, Dequan Dou 1,*, Yuanxia Sun 2 and Lanqing Ma 1,3,*
Can Liu 1,2,3, Longhai Dai 2, Yueping Liu 1,3,*, Long Rong 4, Dequan Dou 1,*, Yuanxia Sun 2 and Lanqing Ma 1,3,*
1
Key Laboratory of Urban Agriculture (North) of Ministry of Agriculture, Beijing University of Agriculture, Beijing 102206, China
2
National Engineering Laboratory for Industrial Enzymes, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China
3
Beijing Collaborative Innovation Center for Eco-Environmental Improvement with Forestry and Fruit Trees, Beijing 102206, China
4
School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
*
Authors to whom correspondence should be addressed.
Nutrients 2016, 8(6), 360; https://doi.org/10.3390/nu8060360
Received: 27 April 2016 / Revised: 27 May 2016 / Accepted: 3 June 2016 / Published: 13 June 2016
(This article belongs to the Special Issue Health-Promoting Components of Fruits and Vegetables in Human Health)
Colorectal cancer and throat cancer are the world’s most prevalent neoplastic diseases, and a serious threat to human health. Plant triterpene glycosides have demonstrated antitumor activity. In this study, we investigated potential anticancer effects of mogroside IVe, a triterpenoid glycoside from monk fruit, using in vitro and in vivo models of colorectal and laryngeal cancer. The effects of mogroside IVe on the proliferation of colorectal cancer HT29 cells and throat cancer Hep-2 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the expression levels of p53, phosphorylated ERK1/2, and MMP-9 were analyzed by western blotting and immunohistochemistry. The results indicated that mogroside IVe inhibited, in a dose-dependent manner, the proliferation of HT29 and Hep-2 cells in culture and in xenografted mice, which was accompanied by the upregulation of tumor suppressor p53, and downregulation of matrix metallopeptidase 9 (MMP-9) and phosphorylated extracellular signal-regulated kinases (ERK)1/2. This study revealed the suppressive activity of mogroside IVe towards colorectal and throat cancers and identified the underlying mechanisms, suggesting that mogroside IVe may be potentially used as a biologically-active phytochemical supplement for treating colorectal and throat cancers.
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Keywords:
mogroside IVe; monk fruit; colorectal cancer; throat cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Liu, C.; Dai, L.; Liu, Y.; Rong, L.; Dou, D.; Sun, Y.; Ma, L. Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer. Nutrients 2016, 8, 360.
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