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Open AccessArticle

Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer

by Can Liu 1,2,3, Longhai Dai 2, Yueping Liu 1,3,*, Long Rong 4, Dequan Dou 1,*, Yuanxia Sun 2 and Lanqing Ma 1,3,*
Key Laboratory of Urban Agriculture (North) of Ministry of Agriculture, Beijing University of Agriculture, Beijing 102206, China
National Engineering Laboratory for Industrial Enzymes, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China
Beijing Collaborative Innovation Center for Eco-Environmental Improvement with Forestry and Fruit Trees, Beijing 102206, China
School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
Authors to whom correspondence should be addressed.
Nutrients 2016, 8(6), 360;
Received: 27 April 2016 / Revised: 27 May 2016 / Accepted: 3 June 2016 / Published: 13 June 2016
(This article belongs to the Special Issue Health-Promoting Components of Fruits and Vegetables in Human Health)
Colorectal cancer and throat cancer are the world’s most prevalent neoplastic diseases, and a serious threat to human health. Plant triterpene glycosides have demonstrated antitumor activity. In this study, we investigated potential anticancer effects of mogroside IVe, a triterpenoid glycoside from monk fruit, using in vitro and in vivo models of colorectal and laryngeal cancer. The effects of mogroside IVe on the proliferation of colorectal cancer HT29 cells and throat cancer Hep-2 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the expression levels of p53, phosphorylated ERK1/2, and MMP-9 were analyzed by western blotting and immunohistochemistry. The results indicated that mogroside IVe inhibited, in a dose-dependent manner, the proliferation of HT29 and Hep-2 cells in culture and in xenografted mice, which was accompanied by the upregulation of tumor suppressor p53, and downregulation of matrix metallopeptidase 9 (MMP-9) and phosphorylated extracellular signal-regulated kinases (ERK)1/2. This study revealed the suppressive activity of mogroside IVe towards colorectal and throat cancers and identified the underlying mechanisms, suggesting that mogroside IVe may be potentially used as a biologically-active phytochemical supplement for treating colorectal and throat cancers. View Full-Text
Keywords: mogroside IVe; monk fruit; colorectal cancer; throat cancer mogroside IVe; monk fruit; colorectal cancer; throat cancer
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Liu, C.; Dai, L.; Liu, Y.; Rong, L.; Dou, D.; Sun, Y.; Ma, L. Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer. Nutrients 2016, 8, 360.

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