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Flavonoids in Inflammatory Bowel Disease: A Review

CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Centre for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n 18016-Armilla, Granada, Spain
Author to whom correspondence should be addressed.
Nutrients 2016, 8(4), 211;
Received: 1 March 2016 / Revised: 19 March 2016 / Accepted: 30 March 2016 / Published: 9 April 2016
(This article belongs to the Special Issue Flavonoids, Inflammation and Immune System)
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the intestine that compromises the patients’ life quality and requires sustained pharmacological and surgical treatments. Since their etiology is not completely understood, non-fully-efficient drugs have been developed and those that have shown effectiveness are not devoid of quite important adverse effects that impair their long-term use. In this regard, a growing body of evidence confirms the health benefits of flavonoids. Flavonoids are compounds with low molecular weight that are widely distributed throughout the vegetable kingdom, including in edible plants. They may be of great utility in conditions of acute or chronic intestinal inflammation through different mechanisms including protection against oxidative stress, and preservation of epithelial barrier function and immunomodulatory properties in the gut. In this review we have revised the main flavonoid classes that have been assessed in different experimental models of colitis as well as the proposed mechanisms that support their beneficial effects. View Full-Text
Keywords: inflammatory bowel disease; flavonoids; oxidative stress; eicosanoids; barrier function; immunomodulatory properties inflammatory bowel disease; flavonoids; oxidative stress; eicosanoids; barrier function; immunomodulatory properties
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MDPI and ACS Style

Vezza, T.; Rodríguez-Nogales, A.; Algieri, F.; Utrilla, M.P.; Rodriguez-Cabezas, M.E.; Galvez, J. Flavonoids in Inflammatory Bowel Disease: A Review. Nutrients 2016, 8, 211.

AMA Style

Vezza T, Rodríguez-Nogales A, Algieri F, Utrilla MP, Rodriguez-Cabezas ME, Galvez J. Flavonoids in Inflammatory Bowel Disease: A Review. Nutrients. 2016; 8(4):211.

Chicago/Turabian Style

Vezza, Teresa, Alba Rodríguez-Nogales, Francesca Algieri, Maria P. Utrilla, Maria E. Rodriguez-Cabezas, and Julio Galvez. 2016. "Flavonoids in Inflammatory Bowel Disease: A Review" Nutrients 8, no. 4: 211.

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