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Open AccessArticle

Efficacy of Synbiotics in Patients with Slow Transit Constipation: A Prospective Randomized Trial

Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Authors to whom correspondence should be addressed.
Nutrients 2016, 8(10), 605;
Received: 27 August 2016 / Revised: 13 September 2016 / Accepted: 22 September 2016 / Published: 28 September 2016
(This article belongs to the Special Issue Dietary Fibers and Human Health)
Synbiotic intake may efficiently restore the balance of gut microbiota and improve gastrointestinal functions. The aim of the study was to evaluate the efficacy of a synbiotic in patients with slow transit constipation. A total of 100 patients with slow transit constipation were randomized to receive either a synbiotic or placebo twice daily for 12 weeks. The primary efficacy endpoints were the clinical remission and improvement rates at weeks 4 and 12. Stool frequency and consistency, colonic transit time (CTT), evacuation and abdominal symptoms, patient assessment of constipation symptoms, gastrointestinal quality-of-life index scores, satisfaction scores, and adverse events were also monitored. The clinical remission rates reached 37.5% at week 4 and 45.8% at week 12 in the treatment group, compared to 13.3% at week 4 and 16.7% at week 12 in the placebo group (p < 0.01 for both comparisons). Over 12 weeks, 64.6% of the patients who received the synbiotic experienced clinical improvement, compared to 29.2% of the patients in the placebo group (p < 0.01). During the intervention period, patients who were treated with the synbiotic exhibited increased stool frequency, improved stool consistency, decreased CTT, and improved constipation-related symptoms. This randomized, placebo-controlled trial suggested that dietary supplementation with a synbiotic improved evacuation-parameters-associated symptoms and colonic motility in patients with slow transit constipation (STC). View Full-Text
Keywords: synbiotic; soluble dietary fiber; slow transit constipation; microbiota synbiotic; soluble dietary fiber; slow transit constipation; microbiota
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Ding, C.; Ge, X.; Zhang, X.; Tian, H.; Wang, H.; Gu, L.; Gong, J.; Zhu, W.; Li, N. Efficacy of Synbiotics in Patients with Slow Transit Constipation: A Prospective Randomized Trial. Nutrients 2016, 8, 605.

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