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Vitamin D Every Day to Keep the Infection Away?

by Juliana De Castro Kroner 1,2,†, Andrea Sommer 1,† and Mario Fabri 1,2,*
1
Department of Dermatology, University of Cologne, 50937 Cologne, Germany
2
Center for Molecular Medicine Cologne, University of Cologne, 50937 Cologne, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2015, 7(6), 4170-4188; https://doi.org/10.3390/nu7064170
Received: 31 March 2015 / Revised: 13 May 2015 / Accepted: 15 May 2015 / Published: 29 May 2015
(This article belongs to the Special Issue Immune Regulation by Vitamin D)
Within the last decade, vitamin D has emerged as a central regulator of host defense against infections. In this regard, vitamin D triggers effective antimicrobial pathways against bacterial, fungal and viral pathogens in cells of the human innate immune system. However, vitamin D also mediates potent tolerogenic effects: it is generally believed that vitamin D attenuates inflammation and acquired immunity, and thus potentially limits collateral tissue damage. Nevertheless, several studies indicate that vitamin D promotes aspects of acquired host defense. Clinically, vitamin D deficiency has been associated with an increased risk for various infectious diseases in epidemiological studies; yet, robust data from controlled trials investigating the use of vitamin D as a preventive or therapeutic agent are missing. In this review, we summarize the current knowledge regarding the effect of vitamin D on innate and acquired host defense, and speculate on the difficulties to translate the available molecular medicine data into practical therapeutic or preventive recommendations. View Full-Text
Keywords: Vitamin D; macrophage; dendritic cell; T cell; infection and immunity Vitamin D; macrophage; dendritic cell; T cell; infection and immunity
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Kroner, J.D.C.; Sommer, A.; Fabri, M. Vitamin D Every Day to Keep the Infection Away? Nutrients 2015, 7, 4170-4188.

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