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Cocoa Bioactive Compounds: Significance and Potential for the Maintenance of Skin Health

Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy
Inter-University Consortium "SannioTech", Benevento 82030, Italy
Division of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, Rome 00173, Italy
Casa Luker S.A., Bogotà DC, Colombia
Dermatology Clinic, University of Catania, Catania 95123, Italy
Department Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy
Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10017, USA
Dermatology Service, Ramon y Cajal Hospital, Madrid 28034, Spain
Author to whom correspondence should be addressed.
Nutrients 2014, 6(8), 3202-3213;
Received: 19 May 2014 / Revised: 17 July 2014 / Accepted: 4 August 2014 / Published: 11 August 2014
Cocoa has a rich history in human use. Skin is prone to the development of several diseases, and the mechanisms in the pathogenesis of aged skin are still poorly understood. However, a growing body of evidence from clinical and bench research has begun to provide scientific validation for the use of cocoa-derived phytochemicals as an effective approach for skin protection. Although the specific molecular and cellular mechanisms of the beneficial actions of cocoa phytochemicals remain to be elucidated, this review will provide an overview of the current literature emphasizing potential cytoprotective pathways modulated by cocoa and its polyphenolic components. Moreover, we will summarize in vivo studies showing that bioactive compounds of cocoa may have a positive impact on skin health. View Full-Text
Keywords: cocoa; skin; health; phytochemicals; antioxidant; anti-inflammatory cocoa; skin; health; phytochemicals; antioxidant; anti-inflammatory
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Scapagnini, G.; Davinelli, S.; Di Renzo, L.; De Lorenzo, A.; Olarte, H.H.; Micali, G.; Cicero, A.F.; Gonzalez, S. Cocoa Bioactive Compounds: Significance and Potential for the Maintenance of Skin Health. Nutrients 2014, 6, 3202-3213.

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