Next Article in Journal
Cocoa Bioactive Compounds: Significance and Potential for the Maintenance of Skin Health
Next Article in Special Issue
Effects of Dietary Fat and Saturated Fat Content on Liver Fat and Markers of Oxidative Stress in Overweight/Obese Men and Women under Weight-Stable Conditions
Previous Article in Journal
Nutrient Intake in Italian Infants and Toddlers from North and South Italy: The Nutrintake 636 Study
Previous Article in Special Issue
The Effects of Choline on Hepatic Lipid Metabolism, Mitochondrial Function and Antioxidative Status in Human Hepatic C3A Cells Exposed to Excessive Energy Substrates
Open AccessArticle

Dietary Fructose Reduction Improves Markers of Cardiovascular Disease Risk in Hispanic-American Adolescents with NAFLD

1
Department of Pediatrics, School of Medicine, Emory University, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA
2
Children's Healthcare of Atlanta, Atlanta, GA 30329, USA
3
Biomarker Core Laboratory, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
4
Department of Radiology, Emory University, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Present address: University of Arizona, Tuscon, AZ 85721, USA.
Nutrients 2014, 6(8), 3187-3201; https://doi.org/10.3390/nu6083187
Received: 6 June 2014 / Revised: 13 July 2014 / Accepted: 30 July 2014 / Published: 8 August 2014
(This article belongs to the Special Issue Nutrition and Liver Disease)
Nonalcoholic fatty liver disease (NAFLD) is now thought to be the most common liver disease worldwide. Cardiovascular complications are a leading cause of mortality in NAFLD. Fructose, a common nutrient in the westernized diet, has been reported to be associated with increased cardiovascular risk, but its impact on adolescents with NAFLD is not well understood. We designed a 4-week randomized, controlled, double-blinded beverage intervention study. Twenty-four overweight Hispanic-American adolescents who had hepatic fat >8% on imaging and who were regular consumers of sweet beverages were enrolled and randomized to calorie-matched study-provided fructose only or glucose only beverages. After 4 weeks, there was no significant change in hepatic fat or body weight in either group. In the glucose beverage group there was significantly improved adipose insulin sensitivity, high sensitivity C-reactive protein (hs-CRP), and low-density lipoprotein (LDL) oxidation. These findings demonstrate that reduction of fructose improves several important factors related to cardiovascular disease despite a lack of measurable improvement in hepatic steatosis. Reducing dietary fructose may be an effective intervention to blunt atherosclerosis progression among NAFLD patients and should be evaluated in longer term clinical trials. View Full-Text
Keywords: nonalcoholic fatty liver disease; hepatic steatosis; fructose; sugar; cardiovascular risk; obesity; children and adolescents nonalcoholic fatty liver disease; hepatic steatosis; fructose; sugar; cardiovascular risk; obesity; children and adolescents
Show Figures

Figure 1

MDPI and ACS Style

Jin, R.; Welsh, J.A.; Le, N.-A.; Holzberg, J.; Sharma, P.; Martin, D.R.; Vos, M.B. Dietary Fructose Reduction Improves Markers of Cardiovascular Disease Risk in Hispanic-American Adolescents with NAFLD. Nutrients 2014, 6, 3187-3201.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop