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Nutrients
Volume 17
Issue 21
10.3390/nu17213416
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Controlling Nutritional Status (CONUT) Score as a Predictor of Prognosis in Non-Small Cell Lung Cancer

by
Raffaella Pagliaro
1,2,*,
Luca Scalfi
3,
Ilaria Di Fiore
1,2,
Anna Leoni
1,2,
Umberto Masi
1,2,
Vito D’Agnano
1,2,
Carmine Picone
4,5,
Filippo Scialò
6,7,
Fabio Perrotta
1,2 and
Andrea Bianco
1,2
1
Department of Translational Medical Sciences, University of Campania “L.Vanvitelli”, 80131 Naples, Italy
2
Clinic of Respiratory Diseases “L. Vanvitelli”, A.O. dei Colli, Monaldi Hospital, 80131 Naples, Italy
3
Department of Public Health, School of Medicine, University of Naples Federico II, 80131 Naples, Italy
4
Division of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Napoli, Italy
5
Department of Medicine and Health Science, Vincenzo Tiberio University of Molise, 86100 Campobasso, Italy
6
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy
7
CEINGE-Biotecnologie Avanzate Franco Salvatore, Via G. Salvatore 486, 80145 Naples, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2025, 17(21), 3416; https://doi.org/10.3390/nu17213416 (registering DOI)
Submission received: 7 October 2025 / Revised: 26 October 2025 / Accepted: 28 October 2025 / Published: 30 October 2025
(This article belongs to the Section Clinical Nutrition)
Review Reports Versions Notes

Abstract

Background: Several studies have reported the association between malnutrition risk and survival outcomes in surgically treated lung cancer patients; in contrast, limited data are available on patients undergoing medical therapies. The aim of this study was to evaluate malnutrition risk (using the CONUT score) and its relationships with treatment response and survival in patients with an advanced stage of non-small cell lung cancer (NSCLC). Methods: We retrospectively evaluated 109 patients with a diagnosis of locally advanced and advanced NSCLC. Patients were assessed at baseline (before any therapy), after four cycles of therapy, and during a follow-up period of 4 yrs. Results: Thirty-two (29.4%) NSCLC patients had a CONUT score ≥ 2. Patients with a higher CONUT score were more likely to have brain metastases while patients with a CONUT score < 2 had a significantly better response to therapy in terms of partial response/stable disease. In addition, The Kaplan–Meier curves revealed a significantly worse prognosis for the high CONUT than the low CONUT group regarding both OS and PFS. Cox regression analysis indicated that the CONUT score (≥2) was as a significant determinant of OS and PFS in the patients studied even after considering other possible predictors. Conclusion: This study suggests that malnutrition risk assessment with CONUT score may be valuable in the prognosis assessment of advanced-stage NSCLC patients.
Keywords: malnutrition; CONUT score; non-small cell lung cancer; survival outcomes; treatment response; nutritional index malnutrition; CONUT score; non-small cell lung cancer; survival outcomes; treatment response; nutritional index

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MDPI and ACS Style

Pagliaro, R.; Scalfi, L.; Di Fiore, I.; Leoni, A.; Masi, U.; D’Agnano, V.; Picone, C.; Scialò, F.; Perrotta, F.; Bianco, A. Controlling Nutritional Status (CONUT) Score as a Predictor of Prognosis in Non-Small Cell Lung Cancer. Nutrients 2025, 17, 3416. https://doi.org/10.3390/nu17213416

AMA Style

Pagliaro R, Scalfi L, Di Fiore I, Leoni A, Masi U, D’Agnano V, Picone C, Scialò F, Perrotta F, Bianco A. Controlling Nutritional Status (CONUT) Score as a Predictor of Prognosis in Non-Small Cell Lung Cancer. Nutrients. 2025; 17(21):3416. https://doi.org/10.3390/nu17213416

Chicago/Turabian Style

Pagliaro, Raffaella, Luca Scalfi, Ilaria Di Fiore, Anna Leoni, Umberto Masi, Vito D’Agnano, Carmine Picone, Filippo Scialò, Fabio Perrotta, and Andrea Bianco. 2025. "Controlling Nutritional Status (CONUT) Score as a Predictor of Prognosis in Non-Small Cell Lung Cancer" Nutrients 17, no. 21: 3416. https://doi.org/10.3390/nu17213416

APA Style

Pagliaro, R., Scalfi, L., Di Fiore, I., Leoni, A., Masi, U., D’Agnano, V., Picone, C., Scialò, F., Perrotta, F., & Bianco, A. (2025). Controlling Nutritional Status (CONUT) Score as a Predictor of Prognosis in Non-Small Cell Lung Cancer. Nutrients, 17(21), 3416. https://doi.org/10.3390/nu17213416

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