Patient and Family Perspectives on Integrated Transitional Care for Anorexia Nervosa in Mantova, Italy
Abstract
1. Introduction
1.1. Beyond Body Mass Index: Diagnostic Migration and Family Burden
1.2. The Service Gap at the Age 18 Boundary
1.3. A 14-to-25 Integrated Service for Lombardy: Policy Framework and Local Implementation
1.4. Evidence Gap and Study Aims
- To establish local age of onset and of first diagnosis in the ED;
- Comparing caregiver-reported satisfaction between two naturalistic cohorts: (a) parents of children under 18 years old treated within child and adolescent mental health services (CAMHS) and (b) parents of patients having completed ≥6 months in the Mantova Transition—ED programme;
- To report on patient-reported satisfaction on a pilot subgroup of nine of the earliest enrolees to the transition pathway and examine it for a relationship with numbers of core clinicians retained beyond the age-18 boundary;
2. Materials and Methods
2.1. Study Design and Setting
2.2. Participants and Recruitment
2.2.1. Caregiver Survey
- They were accompanying a son or daughter to an outpatient consultation with an initial diagnosis of restricting-type anorexia nervosa (AN-R) according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR);
- They had sufficient competence in Italian to respond to a brief computer-based questionnaire;
- They provided written informed consent.
- (I)
- CAMHS: Parent of a patient < 18 years followed by the paediatric arm;
- (II)
- Transition—Adult arm: Parent of a patient ≥ 18 years who, after ≥6 months in the same Transition—ED programme, had moved into its adult arm.
2.2.2. Patient Pilot Survey
- Active treatment ≥6 months within the 14-to-25 Transition—ED pathway;
- First referral to local Adult Mental Health Service between January 2024 and March 2024 (programme start-up);
- Age 18–24 years at the time of the survey;
- Capacity to provide informed consent and complete questionnaires in Italian;
- Initial DSM-5-TR diagnosis of AN-R (as for the parent sample).
2.3. Survey Instruments
- -
- C-Service: perceived impact of a dedicated 14–25 service (the transition model itself) on treatment effectiveness;
- -
- C-Indiv: perceived benefit of keeping the same individual psychotherapist from 14 to 25;
- -
- C-Family: perceived benefit of keeping the same family therapist from 14 to 25;
- -
- C-Diet: perceived benefit of keeping the same dietitian from 14 to 25 (Response anchors: 1 = strongly disagree; 4 = strongly agree).
2.4. Procedure
2.5. Statistical Analysis
- Caregiver comparisons (CAMHS vs. Transition—Adult arm):
- –
- Continuous/ordinal variables: Mann–Whitney U test;
- –
- Categorical variables: Fisher’s exact test.
- Estimation and effect sizes: Alongside p-values, we report effect sizes with 95% CIs—Cliff’s δ for Mann–Whitney tests (CIs via 5000-bootstrap resampling) and Spearman’s ρ (95% CI) for correlations.
- Multiplicity control: The four continuity items were tested in parallel; we therefore applied a Bonferroni-adjusted α = 0.0125 (0.05/4). All other tests used two-tailed α = 0.05.
- Exploratory correlations (e.g., within Transition—Adult caregivers) were used descriptively and were not included in confirmatory hypothesis testing owing to the small sample.
- Patient pilot cohort (n = 9): CSQ-8 was summarised descriptively only (mean ± SD; median; range), with no inferential comparison to caregivers given the convenience sample and the different respondent perspectives.
- Post hoc sensitivity: With n1 = 16 vs. n2 = 15 (two-sided α = 0.05; power 80%), the design would detect only very large between-group effects (approx. Cohen’s d ≈ 1.04, i.e., Cliff’s δ ≈ 0.54). Accordingly, non-significant results should not be interpreted as equivalence.
3. Results
3.1. Caregiver Sample
3.2. Parent-Reported Satisfaction and Continuity Perceptions
3.3. Exploratory Analysis in Transition Caregivers
3.4. Patient-Reported Satisfaction for Early Adopters
- Mean age: 18.9 ± 1.5 years.
- Mean illness duration: 4.0 ± 1.9 years.
- Retained clinicians per age boundary on average: 2.3 ± 0.9.
4. Discussion
Strengths and Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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| Domain | Specific Critical Issue | Typical Consequence |
|---|---|---|
| Early detection and referral | Diagnostic drift unrecognised (AN-R → binge/purge forms) [28,29] | Later presentation to adult team with entrenched behaviours |
| BMI-only focus after weight restoration [38] | Cognitive symptoms underestimated → false “remission” | |
| Service organisation | Age-18 “cliff edge” between CAMHS and AMHS [37] | Up to 50% disengagement within 6 months |
| Divergent treatment cultures (family-centred vs. autonomous) [27] | Abrupt loss of family sessions, rupture of therapeutic alliance | |
| Family involvement | Reluctance to “start over” with new adult team [34] | Reduced parental monitoring just as binge–purge risk rises |
| Caregiver burn-out after crisis phase [36] | Drop-out during maintenance → higher relapse and self-harm | |
| Multidisciplinary continuity | Discontinuity of physicians, dietitian and individual/familiar psychotherapist [39] | Drop-out during transition; stalled cognitive re-processing |
| Fragmented medical–psychiatric records [40] | Delayed detection of osteopenia, cardiac sequelae | |
| Risk management | Surge in impulsivity when binge–purge emerges [32] | Three-fold rise in suicidal ideation/attempts |
| Lack of shared crisis protocols across services [41] | Unplanned emergency admissions, higher costs |
| Component | Operational Detail (ASST Mantova) | Intended Clinical Impact |
|---|---|---|
| Unified MDT | Weekly joint conference with paediatricians, neuro-psychiatrists, adult psychiatrists, internists, dietitians, educators, individual & family therapists | Eliminates hand-over fracture; aligns medical & psychosocial plans |
| Relational continuity | ≥1 constant clinician (psychologist/family therapist/dietitian) accompanies patient across age 18, from CAMHS to Adult services | Preserves therapeutic alliance; buffers stigma & shame |
| Family-centred care | FBT-informed sessions continue into young adulthood; parents receive psycho-education and relapse-prevention coaching | Sustains meal supervision & symptom monitoring when autonomy rises |
| Development-tailored intensity | Case intensity adjusted to developmental milestones (exam periods, university entry, work) rather than chronological age alone | Prevents drop-out at life transitions; supports functional recovery |
| Variable | CAMHS (n = 16) Median [IQR] | Transition—Adult Arm (n = 15) Median [IQR] | p-Value † |
|---|---|---|---|
| Age (years) | 15.0 [13.0–16.0] | 19.0 [18.0–20.5] | <0.001 |
| Age at symptom onset (years) | 13.0 [12.0–14.3] | 15.0 [14.0–16.0] | 0.096 |
| Age at first ED diagnosis (years) | 14.0 [12.0–14.3] | 16.0 [15.0–17.0] | 0.017 |
| Outcome (Likert 1–4 Unless Stated) | CAMHS—Median [IQR] | Transition—Adult Median [IQR] | p-Value † | Cliff’s δ (95% CI) |
|---|---|---|---|---|
| CSQ-8 total (8–32) | 28.5 [26.0–30.8] | 27.0 [24.0–30.0] | 0.750 | −0.071 (−0.488 to 0.333) |
| Dedicated 14–25 service helpful (C-Service/Q9) | 4.0 [3, 4] | 3.0 [2, 4] | 0.192 | −0.242 (−0.568 to 0.104) |
| Same individual psychotherapist (C-Indiv/Q10) | 4.0 [3, 4] | 3.0 [2, 4] | 0.330 | −0.183 (−0.529 to 0.171) |
| Same family therapist (C-Family/Q11) | 3.5 [3, 4] | 3.0 [3, 3] | 0.067 | −0.333 (−0.633 to 0.008) |
| Same dietitian (C-Diet/Q12) | 4.0 [3, 4] | 3.0 [2, 4] | 0.128 | −0.292 (−0.642 to 0.104) |
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Bussolotti, D.; Barillà, G.; Di Genni, A.; Comini, M.; Gallo, A.; Torre, M.; Orlando, L.; Mastrolorenzo, B.; Corradini, E.; Bazzoli, B.; et al. Patient and Family Perspectives on Integrated Transitional Care for Anorexia Nervosa in Mantova, Italy. Nutrients 2025, 17, 2830. https://doi.org/10.3390/nu17172830
Bussolotti D, Barillà G, Di Genni A, Comini M, Gallo A, Torre M, Orlando L, Mastrolorenzo B, Corradini E, Bazzoli B, et al. Patient and Family Perspectives on Integrated Transitional Care for Anorexia Nervosa in Mantova, Italy. Nutrients. 2025; 17(17):2830. https://doi.org/10.3390/nu17172830
Chicago/Turabian StyleBussolotti, Debora, Giovanni Barillà, Antonia Di Genni, Martina Comini, Alberto Gallo, Mariateresa Torre, Laura Orlando, Beatrice Mastrolorenzo, Eva Corradini, Barbara Bazzoli, and et al. 2025. "Patient and Family Perspectives on Integrated Transitional Care for Anorexia Nervosa in Mantova, Italy" Nutrients 17, no. 17: 2830. https://doi.org/10.3390/nu17172830
APA StyleBussolotti, D., Barillà, G., Di Genni, A., Comini, M., Gallo, A., Torre, M., Orlando, L., Mastrolorenzo, B., Corradini, E., Bazzoli, B., Bonfà, F., Mora, A., Pasqualini, L., Mariantoni, E., Cuomo, A., Koukouna, D., & Accorsi, P. (2025). Patient and Family Perspectives on Integrated Transitional Care for Anorexia Nervosa in Mantova, Italy. Nutrients, 17(17), 2830. https://doi.org/10.3390/nu17172830

