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Nutrients
Volume 16
Issue 3
10.3390/nu16030461
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Article

Effects of Multispecies Probiotic Supplementation on Serum Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Trial

by
Marut Vanitchanont
1,
Sakda Arj-Ong Vallibhakara
2,
Areepan Sophonsritsuk
1 and
Orawin Vallibhakara
1,*
1
Reproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
2
Child Safety Promotion and Injury Prevention Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(3), 461; https://doi.org/10.3390/nu16030461
Submission received: 6 January 2024 / Revised: 25 January 2024 / Accepted: 30 January 2024 / Published: 5 February 2024
(This article belongs to the Special Issue Effects of Probiotics on Inflammation and Health Outcomes)
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Abstract

Probiotics have been found to have beneficial effects on bone metabolism. In this randomized, double-blind, placebo-controlled trial, the effects of multispecies probiotic supplementation on bone turnover markers were evaluated after 12 weeks. Forty postmenopausal women with osteopenia were included and randomly divided into two groups. The intervention group received multispecies probiotics, while the control group received identical placebo sachets daily. The baseline characteristics of both groups were similar. Still, the median serum bone resorption marker C-terminal telopeptide of type I collagen (CTX) was slightly higher in the multispecies probiotic group than in the placebo group (0.35 (0.12, 0.53) vs. 0.16 (0.06, 0.75); p-value = 0.004). After 12 weeks, the mean difference in serum CTX at baseline versus 12 weeks was significantly different between the multispecies probiotic and placebo groups (−0.06 (−0.29, 0.05) vs. 0.04 (−0.45, 0.67); p-value < 0.001). The multispecies probiotic group showed a significant decrease in serum CTX at 12 weeks compared with baseline (p-value 0.026). However, the placebo group showed no significant change in serum CTX (p-value 0.18). In conclusion, multispecies probiotics may have a preventive effect on bone through their antiresorptive effect in osteopenic postmenopausal women.
Keywords: probiotics; multispecies probiotics; bone turnover markers; postmenopausal women; osteopenia; supplement; bone health; postmenopausal bone health probiotics; multispecies probiotics; bone turnover markers; postmenopausal women; osteopenia; supplement; bone health; postmenopausal bone health

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MDPI and ACS Style

Vanitchanont, M.; Vallibhakara, S.A.-O.; Sophonsritsuk, A.; Vallibhakara, O. Effects of Multispecies Probiotic Supplementation on Serum Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2024, 16, 461. https://doi.org/10.3390/nu16030461

AMA Style

Vanitchanont M, Vallibhakara SA-O, Sophonsritsuk A, Vallibhakara O. Effects of Multispecies Probiotic Supplementation on Serum Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2024; 16(3):461. https://doi.org/10.3390/nu16030461

Chicago/Turabian Style

Vanitchanont, Marut, Sakda Arj-Ong Vallibhakara, Areepan Sophonsritsuk, and Orawin Vallibhakara. 2024. "Effects of Multispecies Probiotic Supplementation on Serum Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Trial" Nutrients 16, no. 3: 461. https://doi.org/10.3390/nu16030461

APA Style

Vanitchanont, M., Vallibhakara, S. A.-O., Sophonsritsuk, A., & Vallibhakara, O. (2024). Effects of Multispecies Probiotic Supplementation on Serum Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 16(3), 461. https://doi.org/10.3390/nu16030461

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