Next Article in Journal
Is There a Need for Vitamin D Supplements During Summer Time in Northern Germany? A Study of Hospitalised Fracture Patients
Previous Article in Journal
Correction: Ardizzone et al. Efficacy of a Novel Therapeutic, Based on Natural Ingredients and Probiotics, in a Murine Model of Multiple Food Intolerance and Maldigestion. Nutrients 2022, 14, 2251
Previous Article in Special Issue
Results from a Cross-Sectional Observational Study Examining Irritable Bowel Syndrome Patients Six Months After Finishing Their Participation in the ViIBS Trial
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 16
Issue 23
10.3390/nu16234173
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial

by
Lisa Lungaro
1,*,
Patrizia Malfa
2,
Francesca Manza
1,
Anna Costanzini
1,
Guido Valentini
1,
Diletta Francesca Squarzanti
2,
Elisa Viciani
3,
Alena Velichevskaya
3,
Andrea Castagnetti
3,
Marianna Barbalinardo
4,
Denis Gentili
4,
Alessio Cariani
5,
Sara Ghisellini
5,
Fabio Caputo
1,
Roberto De Giorgio
1,6 and
Giacomo Caio
1,7,*
1
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy
2
SynBalance Srl, 21040 Origgio, Italy
3
Wellmicro Srl, 40138 Bologna, Italy
4
Institute for the Study of Nanostructured Materials (CNR-ISMN), National Research Council, 40129 Bologna, Italy
5
Analysis Laboratory, St. Anna Hospital, 44121 Ferrara, Italy
6
Complex Operational Unit of Internal Medicine, S.S. Annunziata Hospital, Cento, 44121 Ferrara, Italy
7
Mucosal Immunology and Biology Research Center, Massachusetts General Hospital-Harvard Medical School, Boston, MA 02114, USA
*
Authors to whom correspondence should be addressed.
Nutrients 2024, 16(23), 4173; https://doi.org/10.3390/nu16234173
Submission received: 31 October 2024 / Revised: 23 November 2024 / Accepted: 29 November 2024 / Published: 30 November 2024
(This article belongs to the Special Issue Interactions between Probiotics, the Gut Microbiome, and Immunity)
Browse Figures
Versions Notes

Abstract

Background: Allergic Rhinitis (AR) is an atopic disease affecting the upper airways of predisposed subjects exposed to aeroallergens. This study evaluates the effects of a mix of specific probiotics (L. acidophilus PBS066, L. rhamnosus LRH020, B. breve BB077, and B. longum subsp. longum BLG240) on symptoms and fecal microbiota modulation in subjects with AR. Methods: Probiotic effects were evaluated at the beginning (T0), at four and eight weeks of treatment (T1 and T2, respectively), and after four weeks of follow-up from the end of treatment (T3) (n = 19) compared to the placebo group (n = 22). AR symptoms and quality of life were evaluated by the mini rhinitis quality of life questionnaire (MiniRQLQ) at each time point. Allergic immune response and fecal microbiota compositions were assessed at T0, T2, and T3. The study was registered on Clinical-Trial.gov (NCT05344352). Results: The probiotic group showed significant improvement in the MiniRQLQ score at T1, T2, and T3 vs. T0 (p < 0.01, p < 0.05, p < 0.01, respectively). At T2, the probiotic group showed an increase in Dorea, which can be negatively associated with allergic diseases, and Fusicatenibacter, an intestinal bacterial genus with anti-inflammatory properties (p-value FDR-corrected = 0.0074 and 0.013, respectively). Conversely, at T3 the placebo group showed an increase in Bacteroides and Ruminococcaceae unassigned, (p-value FDR-corrected = 0.033 and 0.023, respectively) which can be associated with allergies, while the probiotic group showed a significative increase in the Prevotella/Bacteroides ratio (p-value FDR-corrected = 0.023). Conclusions: This probiotic formulation improves symptoms and quality of life in subjects with AR, promoting a shift towards anti-inflammatory and anti-allergic bacterial species in the intestinal microbiota.
Keywords: allergic rhinitis; immune system; inflammation; microbiota; probiotics allergic rhinitis; immune system; inflammation; microbiota; probiotics

Share and Cite

MDPI and ACS Style

Lungaro, L.; Malfa, P.; Manza, F.; Costanzini, A.; Valentini, G.; Squarzanti, D.F.; Viciani, E.; Velichevskaya, A.; Castagnetti, A.; Barbalinardo, M.; et al. Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial. Nutrients 2024, 16, 4173. https://doi.org/10.3390/nu16234173

AMA Style

Lungaro L, Malfa P, Manza F, Costanzini A, Valentini G, Squarzanti DF, Viciani E, Velichevskaya A, Castagnetti A, Barbalinardo M, et al. Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial. Nutrients. 2024; 16(23):4173. https://doi.org/10.3390/nu16234173

Chicago/Turabian Style

Lungaro, Lisa, Patrizia Malfa, Francesca Manza, Anna Costanzini, Guido Valentini, Diletta Francesca Squarzanti, Elisa Viciani, Alena Velichevskaya, Andrea Castagnetti, Marianna Barbalinardo, and et al. 2024. "Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial" Nutrients 16, no. 23: 4173. https://doi.org/10.3390/nu16234173

APA Style

Lungaro, L., Malfa, P., Manza, F., Costanzini, A., Valentini, G., Squarzanti, D. F., Viciani, E., Velichevskaya, A., Castagnetti, A., Barbalinardo, M., Gentili, D., Cariani, A., Ghisellini, S., Caputo, F., De Giorgio, R., & Caio, G. (2024). Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial. Nutrients, 16(23), 4173. https://doi.org/10.3390/nu16234173

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop