Next Article in Journal
Associations of Cognitive Function with Serum Magnesium and Phosphate in Hemodialysis Patients: A Cross-Sectional Analysis of the Osaka Dialysis Complication Study (ODCS)
Previous Article in Journal
Impact of Dietary Fatty Acid Composition on the Intestinal Microbiota and Fecal Metabolism of Rats Fed a High-Fructose/High-Fat Diet
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 16
Issue 21
10.3390/nu16213775
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women—A Pilot Randomized Clinical Trial

by
Araceli Montoya-Estrada
1,
Aline Yunuen García-Cortés
2,
José Romo-Yañez
1,
Guillermo F. Ortiz-Luna
3,
Arturo Arellano-Eguiluz
3,
Aurora Belmont-Gómez
4,
Vivian Lopéz-Ugalde
4,
Guadalupe León-Reyes
5,
Arturo Flores-Pliego
6,
Aurora Espejel-Nuñez
6,
Juan Mario Solis-Paredes
7 and
Enrique Reyes-Muñoz
8,*
1
Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology, Ministry of Health, Mexico City 11000, Mexico
2
Human Reproductive Biology, National Institute of Perinatology, Ministry of Health, Mexico City 11000, Mexico
3
Peri and Postmenopause Clinic, National Institute of Perinatology, Ministry of Health, Mexico City 11000, Mexico
4
Coordination of Clinical Pharmacology, National Institute of Perinatology, Ministry of Health, Mexico City 11000, Mexico
5
Nutrigenetics and Nutrigenomics Laboratory, National Institute of Genomic Medicine, Ministry of Health, Mexico City 14610, Mexico
6
Department of Immunobiochemistry, National Institute of Perinatology, Ministry of Health, Mexico City 11000, Mexico
7
Clinical Research Branch, National Institute of Perinatology, Ministry of Health, Mexico City 11000, Mexico
8
Research Direction, National Institute of Perinatology, Ministry of Health, Mexico City 11000, Mexico
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(21), 3775; https://doi.org/10.3390/nu16213775
Submission received: 3 September 2024 / Revised: 25 October 2024 / Accepted: 30 October 2024 / Published: 3 November 2024
(This article belongs to the Section Phytochemicals and Human Health)
Browse Figures
Review Reports Versions Notes

Abstract

In postmenopausal women, due to endocrine changes, there is an increase in oxidative stress (OS) that predisposes them to cardiovascular and metabolic alterations. Sixty-one percent of women in this stage require a primary therapeutic strategy to decrease OS. This study aimed to evaluate the effect of resveratrol and vitamin C on OS in postmenopausal women. A randomized, double-blind clinical trial was carried out. Forty-six postmenopausal women with insulin resistance (HOMA-IR > 2.5) were included and divided into three treatment groups: group A: resveratrol, n = 13; group B: resveratrol + vitamin C, n = 15; and group C: vitamin C, n = 14. Between before and after the antioxidants, group B showed a decrease of 33% in lipohydroperoxides (p = 0.02), and malondialdehyde (MDA) decreased by 26% (p = 0.0007), 32% (p = 0.0001), and 38% (p = 0.0001) in groups A–C, respectively. For protein damage, group B is the most representative, with a decrease of 39% (p = 0.0001). For total antioxidant capacity (TAC), there were significant increases of 30% and 28% in groups B and C, respectively. For HOMA-IR, there were no significant differences among the study groups. Supplementation with this combination of antioxidants significantly decreases markers of OS in postmenopausal women. In addition, it increases TAC by up to 30%.
Keywords: oxidative stress; postmenopause; antioxidants; polyphenol; protein damage; total antioxidant capacity; malondialdehyde; insulin resistance oxidative stress; postmenopause; antioxidants; polyphenol; protein damage; total antioxidant capacity; malondialdehyde; insulin resistance

Share and Cite

MDPI and ACS Style

Montoya-Estrada, A.; García-Cortés, A.Y.; Romo-Yañez, J.; Ortiz-Luna, G.F.; Arellano-Eguiluz, A.; Belmont-Gómez, A.; Lopéz-Ugalde, V.; León-Reyes, G.; Flores-Pliego, A.; Espejel-Nuñez, A.; et al. The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women—A Pilot Randomized Clinical Trial. Nutrients 2024, 16, 3775. https://doi.org/10.3390/nu16213775

AMA Style

Montoya-Estrada A, García-Cortés AY, Romo-Yañez J, Ortiz-Luna GF, Arellano-Eguiluz A, Belmont-Gómez A, Lopéz-Ugalde V, León-Reyes G, Flores-Pliego A, Espejel-Nuñez A, et al. The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women—A Pilot Randomized Clinical Trial. Nutrients. 2024; 16(21):3775. https://doi.org/10.3390/nu16213775

Chicago/Turabian Style

Montoya-Estrada, Araceli, Aline Yunuen García-Cortés, José Romo-Yañez, Guillermo F. Ortiz-Luna, Arturo Arellano-Eguiluz, Aurora Belmont-Gómez, Vivian Lopéz-Ugalde, Guadalupe León-Reyes, Arturo Flores-Pliego, Aurora Espejel-Nuñez, and et al. 2024. "The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women—A Pilot Randomized Clinical Trial" Nutrients 16, no. 21: 3775. https://doi.org/10.3390/nu16213775

APA Style

Montoya-Estrada, A., García-Cortés, A. Y., Romo-Yañez, J., Ortiz-Luna, G. F., Arellano-Eguiluz, A., Belmont-Gómez, A., Lopéz-Ugalde, V., León-Reyes, G., Flores-Pliego, A., Espejel-Nuñez, A., Solis-Paredes, J. M., & Reyes-Muñoz, E. (2024). The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women—A Pilot Randomized Clinical Trial. Nutrients, 16(21), 3775. https://doi.org/10.3390/nu16213775

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop