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Nutrients
Volume 16
Issue 13
10.3390/nu16131988
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Article

Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

by
Jela Hrnciarova
1,2,
Klara Kubelkova
3,*,
Vanda Bostik
3,
Ivan Rychlik
4,
Daniela Karasova
4,
Vladimir Babak
4,
Magdalena Datkova
1,2,
Katerina Simackova
1,2 and
Ales Macela
3
1
Faculty of Medicine, Charles University, 500 03 Hradec Kralove, Czech Republic
2
Department of Psychiatry, University Hospital in Hradec Kralove, 500 03 Hradec Kralove, Czech Republic
3
Military Faculty of Medicine, University of Defence, 500 03 Hradec Kralove, Czech Republic
4
Veterinary Research Institute, 621 00 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(13), 1988; https://doi.org/10.3390/nu16131988
Submission received: 12 May 2024 / Revised: 18 June 2024 / Accepted: 19 June 2024 / Published: 21 June 2024
(This article belongs to the Special Issue The Effect of Nutrients on Neurological Disorders)
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Abstract

The etiology and mechanisms of autism and autism spectrum disorder (ASD) are not yet fully understood. There is currently no treatment for ASD for providing significant improvement in core symptoms. Recent studies suggest, however, that ASD is associated with gut dysbiosis, indicating that modulation of gut microbiota in children with ASD may thus reduce the manifestation of ASD symptoms. The aim of this pilot study (prospective randomized, double-blinded, placebo-controlled) was to evaluate efficacy of the biological response modifier Juvenil in modulating the microbiome of children with ASD and, in particular, whether Juvenil is able to alleviate the symptoms of ASD. In total, 20 children with ASD and 12 neurotypical children were included in our study. Supplementation of ASD children lasted for three months. To confirm Juvenil’s impact on the gut microbiome, stool samples were collected from all children and the microbiome’s composition was analyzed. This pilot study demonstrated that the gut microbiome of ASD children differed significantly from that of healthy controls and was converted by Juvenil supplementation toward a more neurotypical microbiome that positively modulated children’s autism symptoms.
Keywords: autism; microbiome; biological response modifier; psychobiotics autism; microbiome; biological response modifier; psychobiotics

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MDPI and ACS Style

Hrnciarova, J.; Kubelkova, K.; Bostik, V.; Rychlik, I.; Karasova, D.; Babak, V.; Datkova, M.; Simackova, K.; Macela, A. Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study. Nutrients 2024, 16, 1988. https://doi.org/10.3390/nu16131988

AMA Style

Hrnciarova J, Kubelkova K, Bostik V, Rychlik I, Karasova D, Babak V, Datkova M, Simackova K, Macela A. Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study. Nutrients. 2024; 16(13):1988. https://doi.org/10.3390/nu16131988

Chicago/Turabian Style

Hrnciarova, Jela, Klara Kubelkova, Vanda Bostik, Ivan Rychlik, Daniela Karasova, Vladimir Babak, Magdalena Datkova, Katerina Simackova, and Ales Macela. 2024. "Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study" Nutrients 16, no. 13: 1988. https://doi.org/10.3390/nu16131988

APA Style

Hrnciarova, J., Kubelkova, K., Bostik, V., Rychlik, I., Karasova, D., Babak, V., Datkova, M., Simackova, K., & Macela, A. (2024). Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study. Nutrients, 16(13), 1988. https://doi.org/10.3390/nu16131988

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