Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review
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Department of Obstetrics and Gynecology, Semmelweis University, Üllői Street 78/a, 1082 Budapest, Hungary
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Workgroup of Research Management, Doctoral School, Semmelweis University, Üllői Street 22, 1085 Budapest, Hungary
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Department of Internal Medicine and Oncology, Semmelweis University, Sándor Korányi Street 2/a, 1098 Budapest, Hungary
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EndoCare Institute, Endocrinology Center, Bokor Street 17-21, 1037 Budapest, Hungary
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Department of Physiology, Semmelweis University, Tűzoltó Street 37-47, 1094 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Academic Editor: Jose M. Valdivielso
Nutrients 2022, 14(8), 1649; https://doi.org/10.3390/nu14081649
Received: 16 March 2022
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Revised: 9 April 2022
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Accepted: 11 April 2022
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Published: 15 April 2022
(This article belongs to the Special Issue Vitamin D Receptor in Human Health and Disease)
Polycystic ovary syndrome (PCOS) is one of the most common endocrine reproductive disorders in women. Vitamin D deficiency is also quite common in this condition. The degree of vitamin D deficiency correlates with the severity of PCOS. Both male and female vitamin D levels play a role in fertility and affect the outcomes of in vitro fertilization (IVF). Moreover, fertility and IVF indicators are improved by vitamin D not only in healthy women but in those diagnosed with PCOS. Both vitamin D deficiency and PCOS increase pregnancy-related complications. Vitamin D supplementation and optimal vitamin D levels decrease both maternal and fetal risk for complications and adverse events. Furthermore, vitamin D supplementation may ameliorate or even prevent pregnancy-related reversible bone loss in mothers. This review emphasizes the roles of vitamin D deficiency and vitamin D supplementation and their correlation with PCOS regarding reproductive health.
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Keywords:
polycystic ovary syndrome; PCOS; vitamin D; vitamin D deficiency; vitamin D supplementation; female fertility; male fertility; in vitro fertilization; pregnancy; reproductive health
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MDPI and ACS Style
Várbíró, S.; Takács, I.; Tűű, L.; Nas, K.; Sziva, R.E.; Hetthéssy, J.R.; Török, M. Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review. Nutrients 2022, 14, 1649. https://doi.org/10.3390/nu14081649
AMA Style
Várbíró S, Takács I, Tűű L, Nas K, Sziva RE, Hetthéssy JR, Török M. Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review. Nutrients. 2022; 14(8):1649. https://doi.org/10.3390/nu14081649
Chicago/Turabian StyleVárbíró, Szabolcs, István Takács, László Tűű, Katalin Nas, Réka E. Sziva, Judit R. Hetthéssy, and Marianna Török. 2022. "Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review" Nutrients 14, no. 8: 1649. https://doi.org/10.3390/nu14081649
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