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Article

Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity

1
Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
2
Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
3
Department of Human Immunology and Nutrition Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
4
Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi 510-0844, Japan
5
AiSTI Science Co., Ltd., Wakayama 640-8390, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Wojciech Kolanowski
Nutrients 2022, 14(6), 1157; https://doi.org/10.3390/nu14061157
Received: 27 January 2022 / Revised: 1 March 2022 / Accepted: 4 March 2022 / Published: 9 March 2022
(This article belongs to the Topic Applied Sciences in Functional Foods)
Partially hydrolyzed guar gum (PHGG) is a soluble dietary fiber derived through controlled enzymatic hydrolysis of guar gum, a highly viscous galactomannan derived from the seeds of Cyamopsis tetragonoloba. Here, we examined the therapeutic potential of dietary supplementation with PHGG against sarcopenic obesity using Db/Db mice. Db/Db mice fed a normal diet alone or a fiber-free diet, or supplemented with a diet containing PHGG (5%), were examined. PHGG increased grip strength and the weight of skeletal muscles. PHGG increased the short-chain fatty acids (SCFAs) concentration in feces and sera. Concerning innate immunity, PHGG decreased the ratio of inflammatory cells, while increasing the ratio of anti-inflammatory cells in the small intestine. The present study demonstrated the preventive effect of PHGG on sarcopenic obesity. Changes in nutrient absorption might be involved through the promotion of an anti-inflammatory shift of innate immunity in the intestine accompanied by an increase in SCFA production by PHGG. View Full-Text
Keywords: partially hydrolyzed guar gum; PHGG; sarcopenic obesity; metabolite; innate immunity partially hydrolyzed guar gum; PHGG; sarcopenic obesity; metabolite; innate immunity
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MDPI and ACS Style

Okamura, T.; Hamaguchi, M.; Mori, J.; Yamaguchi, M.; Mizushima, K.; Abe, A.; Ozeki, M.; Sasano, R.; Naito, Y.; Fukui, M. Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity. Nutrients 2022, 14, 1157. https://doi.org/10.3390/nu14061157

AMA Style

Okamura T, Hamaguchi M, Mori J, Yamaguchi M, Mizushima K, Abe A, Ozeki M, Sasano R, Naito Y, Fukui M. Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity. Nutrients. 2022; 14(6):1157. https://doi.org/10.3390/nu14061157

Chicago/Turabian Style

Okamura, Takuro, Masahide Hamaguchi, Jun Mori, Mihoko Yamaguchi, Katsura Mizushima, Aya Abe, Makoto Ozeki, Ryoichi Sasano, Yuji Naito, and Michiaki Fukui. 2022. "Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity" Nutrients 14, no. 6: 1157. https://doi.org/10.3390/nu14061157

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