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Article

Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia

1
NUTREN-Nutrigenomics, Department of Experimental Medicine, University of Lleida, 25198 Lleida, Spain
2
Institut Català de la Salut, 08028 Barcelona, Spain
3
Department of Basic Medical Sciences, University of Lleida, 25198 Lleida, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Valentini Konstantinidou and Sarela Garcia-Santamarina
Nutrients 2022, 14(3), 525; https://doi.org/10.3390/nu14030525
Received: 21 December 2021 / Revised: 12 January 2022 / Accepted: 19 January 2022 / Published: 25 January 2022
(This article belongs to the Special Issue The Effect of Gene-Diet Interactions in Human Health)
This study aimed to determine how the microbiota profile might be predisposed to a better response in blood lipid profiles due to dietary fibre supplementation. A three-arm intervention study that included three different fibre types (mainly insoluble, soluble, and antioxidant fibre) supplemented (19.2 g/day) during 2 months in individuals with hypercholesterolemia was developed. Changes in faecal microbiota and blood lipid profile after fibre supplementation were determined. In all volunteers, regardless of fibre type, an increase in the abundance of Bifidobacterium was observed, and similarly, an inverse relationship between faecal propionic acid and blood LDL-cholesterol, LDL particle size, and LDL/HDL particle ratio (p-values 0.0067, 0.0002, and 0.0067, respectively) was observed. However, not all volunteers presented an improvement in lipid profile. The non-responders to fibre treatment showed a decrease in microbiota diversity (Shannon and Simpson diversity index p-values of 0.0110 and 0.0255, respectively) after the intervention; where the reduction in short-chain fatty acids (SCFAs) producing bacterial genera such as Clostridium XIVa and Ruminococcus after dietary fibre treatment was the main difference. It was concluded that the non-responsiveness to dietary fibre treatment might be mediated by the lack of ability to maintain a stable SCFA producing bacteria diversity and composition after extra fibre intake. View Full-Text
Keywords: dietary fibre; cholesterol; blood lipid profile; colonic microbiota dietary fibre; cholesterol; blood lipid profile; colonic microbiota
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MDPI and ACS Style

Granado-Serrano, A.B.; Martín-Garí, M.; Sánchez, V.; Riart Solans, M.; Lafarga Giribets, A.; Berdún, R.; Vilaprinyó, E.; Portero-Otín, M.; Serrano, J.C.E. Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia. Nutrients 2022, 14, 525. https://doi.org/10.3390/nu14030525

AMA Style

Granado-Serrano AB, Martín-Garí M, Sánchez V, Riart Solans M, Lafarga Giribets A, Berdún R, Vilaprinyó E, Portero-Otín M, Serrano JCE. Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia. Nutrients. 2022; 14(3):525. https://doi.org/10.3390/nu14030525

Chicago/Turabian Style

Granado-Serrano, Ana B., Meritxell Martín-Garí, Virginia Sánchez, Marissa Riart Solans, Antonia Lafarga Giribets, Rebeca Berdún, Ester Vilaprinyó, Manuel Portero-Otín, and José C.E. Serrano. 2022. "Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia" Nutrients 14, no. 3: 525. https://doi.org/10.3390/nu14030525

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