Neuroprotective Effects of Betulinic Acid Hydroxamate in Intraventricular Hemorrhage-Induced Brain Damage in Immature Rats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. IVH Induction
2.3. MRI Studies
2.4. Neurobehavioral Studies
2.5. Histologic Studies
2.6. Biochemical and Molecular Studies
2.7. Spectroscopy Studies
2.8. Statistical Analysis
3. Results
3.1. IVH-Induced Brain Damage
3.2. Functional Consequences of IVH
3.3. Long Term WMI Jury after IVH
3.4. Mechanisms of Brain Injury
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Del Pozo, A.; Silva, L.; Romero, A.; De Hoz-Rivera, M.; Villa, M.; Martínez-Vega, M.; Prados, M.E.; Muñoz, E.; Martínez-Orgado, J. Neuroprotective Effects of Betulinic Acid Hydroxamate in Intraventricular Hemorrhage-Induced Brain Damage in Immature Rats. Nutrients 2022, 14, 5286. https://doi.org/10.3390/nu14245286
Del Pozo A, Silva L, Romero A, De Hoz-Rivera M, Villa M, Martínez-Vega M, Prados ME, Muñoz E, Martínez-Orgado J. Neuroprotective Effects of Betulinic Acid Hydroxamate in Intraventricular Hemorrhage-Induced Brain Damage in Immature Rats. Nutrients. 2022; 14(24):5286. https://doi.org/10.3390/nu14245286
Chicago/Turabian StyleDel Pozo, Aarón, Laura Silva, Angela Romero, María De Hoz-Rivera, María Villa, María Martínez-Vega, María Eugenia Prados, Eduardo Muñoz, and José Martínez-Orgado. 2022. "Neuroprotective Effects of Betulinic Acid Hydroxamate in Intraventricular Hemorrhage-Induced Brain Damage in Immature Rats" Nutrients 14, no. 24: 5286. https://doi.org/10.3390/nu14245286