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Article

Vitamin D Deficiency Is Associated with Glycometabolic Changes in Nondiabetic Patients with Arterial Hypertension

Department of Medicine, Clinica Medica, University of Udine, 33100 Udine, Italy
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Přemysl Mladěnka, Laura Mercolini and Fernando Remião
Nutrients 2022, 14(2), 311; https://doi.org/10.3390/nu14020311
Received: 27 December 2021 / Revised: 7 January 2022 / Accepted: 10 January 2022 / Published: 12 January 2022
Recent evidence indicates that mildly increased fasting and post-oral load blood glucose concentrations contribute to development of organ damage in nondiabetic patients with hypertension. In previous studies, vitamin D deficiency was associated with decreased glucose tolerance. The aim of this study was to examine the relationships between serum 25(OH)D levels and glucose tolerance and insulin sensitivity in hypertension. In 187 nondiabetic essential hypertensive patients free of cardiovascular or renal complications, we measured serum 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) and performed a standard oral glucose tolerance test (OGTT). Patients with 25(OH)D deficiency/insufficiency were older and had significantly higher blood pressure, fasting and post-OGTT (G-AUC) glucose levels, post-OGTT insulin (I-AUC), PTH levels, and prevalence of metabolic syndrome than patients with normal serum 25(OH)D. 25(OH)D levels were inversely correlated with age, blood pressure, fasting glucose, G-AUC, triglycerides, and serum calcium and PTH, while no significant relationships were found with body mass index (BMI), fasting insulin, I-AUC, HOMA index, and renal function. In a multivariate regression model, greater G-AUC was associated with lower 25(OH)D levels independently of BMI and seasonal vitamin D variations. Thus, in nondiabetic hypertensive patients, 25(OH)D deficiency/insufficiency could contribute to impaired glucose tolerance without directly affecting insulin sensitivity. View Full-Text
Keywords: glucose tolerance; hypertension; insulin resistance; parathyroid hormone; vitamin D glucose tolerance; hypertension; insulin resistance; parathyroid hormone; vitamin D
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MDPI and ACS Style

Brosolo, G.; Da Porto, A.; Bulfone, L.; Scandolin, L.; Vacca, A.; Bertin, N.; Vivarelli, C.; Sechi, L.A.; Catena, C. Vitamin D Deficiency Is Associated with Glycometabolic Changes in Nondiabetic Patients with Arterial Hypertension. Nutrients 2022, 14, 311. https://doi.org/10.3390/nu14020311

AMA Style

Brosolo G, Da Porto A, Bulfone L, Scandolin L, Vacca A, Bertin N, Vivarelli C, Sechi LA, Catena C. Vitamin D Deficiency Is Associated with Glycometabolic Changes in Nondiabetic Patients with Arterial Hypertension. Nutrients. 2022; 14(2):311. https://doi.org/10.3390/nu14020311

Chicago/Turabian Style

Brosolo, Gabriele, Andrea Da Porto, Luca Bulfone, Laura Scandolin, Antonio Vacca, Nicole Bertin, Cinzia Vivarelli, Leonardo A. Sechi, and Cristiana Catena. 2022. "Vitamin D Deficiency Is Associated with Glycometabolic Changes in Nondiabetic Patients with Arterial Hypertension" Nutrients 14, no. 2: 311. https://doi.org/10.3390/nu14020311

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