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Article

The Relationship between Body Composition, Dietary Intake, Physical Activity, and Pulmonary Status in Adolescents and Adults with Cystic Fibrosis

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Division of Endocrinology, Boston Children’s Hospital, Boston, MA 02115, USA
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Harvard Medical School, Boston, MA 02115, USA
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Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital, Boston, MA 02115, USA
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Division of Gastroenterology, Beth Israel Deaconess Hospital, Boston, MA 02115, USA
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Division of Pulmonary Medicine, Boston Children’s Hospital, Boston, MA 02115, USA
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Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA
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Division of Endocrinology, Massachusetts General Hospital, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Maria R. Mascarenhas and Jessica Alvarez
Nutrients 2022, 14(2), 310; https://doi.org/10.3390/nu14020310
Received: 10 December 2021 / Revised: 7 January 2022 / Accepted: 10 January 2022 / Published: 12 January 2022
(This article belongs to the Special Issue Nutritional Management of Cystic Fibrosis)
Measures of body fat and lean mass may better predict important clinical outcomes in patients with cystic fibrosis (CF) than body mass index (BMI). Little is known about how diet quality and exercise may impact body composition in these patients. Dual X-ray absorptiometry (DXA) body composition, 24-h dietary recall, and physical activity were assessed in a cross-sectional analysis of 38 adolescents and adults with CF and 19 age-, race-, and gender-matched healthy volunteers. Compared with the healthy volunteers, participants with CF had a lower appendicular lean mass index (ALMI), despite no observed difference in BMI, and their diets consisted of higher glycemic index foods with a greater proportion of calories from fat and a lower proportion of calories from protein. In participants with CF, pulmonary function positively correlated with measures of lean mass, particularly ALMI, and negatively correlated with multiple measures of body fat after controlling for age, gender, and BMI. Higher physical activity levels were associated with greater ALMI and lower body fat. In conclusion, body composition measures, particularly ALMI, may better predict key clinical outcomes in individuals with CF than BMI. Future longitudinal studies analyzing the effect of dietary intake and exercise on body composition and CF-specific clinical outcomes are needed. View Full-Text
Keywords: body composition; cystic fibrosis; dual-energy X-ray absorptiometry; lean body mass; appendicular lean mass index; fat mass index; dietary intake body composition; cystic fibrosis; dual-energy X-ray absorptiometry; lean body mass; appendicular lean mass index; fat mass index; dietary intake
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MDPI and ACS Style

Scully, K.J.; Jay, L.T.; Freedman, S.; Sawicki, G.S.; Uluer, A.; Finkelstein, J.S.; Putman, M.S. The Relationship between Body Composition, Dietary Intake, Physical Activity, and Pulmonary Status in Adolescents and Adults with Cystic Fibrosis. Nutrients 2022, 14, 310. https://doi.org/10.3390/nu14020310

AMA Style

Scully KJ, Jay LT, Freedman S, Sawicki GS, Uluer A, Finkelstein JS, Putman MS. The Relationship between Body Composition, Dietary Intake, Physical Activity, and Pulmonary Status in Adolescents and Adults with Cystic Fibrosis. Nutrients. 2022; 14(2):310. https://doi.org/10.3390/nu14020310

Chicago/Turabian Style

Scully, Kevin J., Laura T. Jay, Steven Freedman, Gregory S. Sawicki, Ahmet Uluer, Joel S. Finkelstein, and Melissa S. Putman. 2022. "The Relationship between Body Composition, Dietary Intake, Physical Activity, and Pulmonary Status in Adolescents and Adults with Cystic Fibrosis" Nutrients 14, no. 2: 310. https://doi.org/10.3390/nu14020310

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