Dahl Salt-Resistant Rat Is Protected against Hypertension during Diet-Induced Obesity
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Blood Pressure Measurements
2.3. Histological Analysis
2.4. Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR)
2.5. Measurement of Cytokine Levels
2.6. Statistics
3. Results
3.1. HFD Increased Blood Pressure Only in SS Rats Regardless of Accelerated Body Weight Gain in Both Rats
3.2. HFD Increased the Adipocyte Area in the SS Rats Regardless of Increased tPVAT Weight in Both Rats
3.3. HFD Did Not Affect the Expression of Genes Related to Adipocyte Markers in tPVAT of SS and SR Rats
3.4. HFD Did Not Affect the Expression of the Inflammatory or Contractile Factors in tPVAT of SS and SR Rats
3.5. HFD Did Not Affect the Expression of Genes Related to RAAS in the Kidney of SS and SR Rats
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Lee, S.; Jang, S.; Kim, J.Y.; Kim, I. Dahl Salt-Resistant Rat Is Protected against Hypertension during Diet-Induced Obesity. Nutrients 2022, 14, 3843. https://doi.org/10.3390/nu14183843
Lee S, Jang S, Kim JY, Kim I. Dahl Salt-Resistant Rat Is Protected against Hypertension during Diet-Induced Obesity. Nutrients. 2022; 14(18):3843. https://doi.org/10.3390/nu14183843
Chicago/Turabian StyleLee, Soyung, Sungmin Jang, Jee Young Kim, and Inkyeom Kim. 2022. "Dahl Salt-Resistant Rat Is Protected against Hypertension during Diet-Induced Obesity" Nutrients 14, no. 18: 3843. https://doi.org/10.3390/nu14183843