Non-Pharmacological Self-Management Strategies for Chemotherapy-Induced Peripheral Neuropathy in People with Advanced Cancer: A Systematic Review and Meta-Analysis

Round 1

Reviewer 1 Report

This  systematic review and meta-analysise is carefully conducted using the correct procedures. Quality assurance is also well controlled. I believe that these evidences will help people with advanced cancer.

Reviewer 2 Report

In the present review “Non-pharmacological self-management strategies for chemotherapy-induced peripheral neuropathy in people with advanced cancer: A systematic review and meta-analysis”, Megan Crichton and colleagues sought to determine the effect of non-pharmacological self-management interventions on the incidence and severity of chemotherapy-induced peripheral neurotherapy (CIPN) symptoms and CIPN-related outcomes (quality of life, physical function, sleep, fatigue, gastrointestinal symptoms, nutrition status, psychosocial and financial outcomes, and adverse effects) compared to any control condition. So far, they concluded that the strongest evidence with the most certainty was found for physical exercise as a safe and viable adjuvant to chemotherapy treatment for the prevention and management of CIPN and related physical function in people with advanced cancer. Moreover, nutrition supplements of glutamine and an Omega-3 PUFA-enriched drink showed some benefit, and the use of interactive technology may facilitate education for self-management of CIPN; however, certainty in these effects was very low. Of course, future clinical trials should be rigorously designed and reported to include adequate sample size, clearly defined populations, and interventions, and use valid outcome measures. Overall, I think that the manuscript is intriguing, well-written (within the scope of this journal), well-structured and the data are of clinical relevance on a current topic of interest. I would like to congratulate the authors on their work.