Next Article in Journal
Vitamin A Plasma Levels in COVID-19 Patients: A Prospective Multicenter Study and Hypothesis
Next Article in Special Issue
Effect of Nutritional Supplementation on Oxidative Stress and Hormonal and Lipid Profiles in PCOS-Affected Females
Previous Article in Journal
Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial
 
 
Article

Beneficial Effects of a Specially Designed Home Meal Replacement on Cardiometabolic Parameters in Individuals with Obesity: Preliminary Results of a Randomized Controlled Clinical Trial

1
Department of Family Medicine, Chungbuk National University Hospital, Cheongju 28644, Korea
2
Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea
3
Greengrassbio, Incorporated, Chungju 27462, Korea
4
Department of Family Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Karolina Szewczyk-Golec
Nutrients 2021, 13(7), 2171; https://doi.org/10.3390/nu13072171
Received: 6 May 2021 / Revised: 18 June 2021 / Accepted: 22 June 2021 / Published: 24 June 2021
(This article belongs to the Special Issue Specialized Diet, Obesity and Associated Metabolic Disorders)
We aimed to investigate if a home meal replacement (HMR), designed with a low ω-6/ω-3 fatty acid ratio, improves cardiometabolic parameters, including metabolic syndrome (MetS) in obese individuals. We conducted a monocentric, controlled, randomized crossover trial. The HMR contains higher protein and fat content, lower carbohydrate content, and a lower ω6FA/ω3FA ratio than the regular diet. Sixty-four participants were randomized into two groups and switched to the other group following a 4-week intervention. While subjects in the HMR group were provided three HMRs daily, those in the control group were requested to maintain their regular dietary pattern. We conducted paired t-tests, repeated measures analysis of variance, and McNemar tests before and after the intervention. Body mass index (BMI) and weight were lower in the HMR group after adjusting for age, sex, and total energy intake and significantly changed in the between-group differences. The waist circumference, systolic blood pressure, triglycerides, triglyceride–glucose index, and triglyceride to high-density lipoprotein cholesterol ratio were reduced in the HMR group (all p < 0.05). The percentage of subjects with MetS significantly decreased from 39.1% at baseline to 28.1% post-intervention (p = 0.035). Using the HMR for 4 weeks reduced the BMI, weight, and MetS prevalence in individuals with obesity. This trial was registered at clinicaltrials.gov (NCT04552574). View Full-Text
Keywords: omega-3 fatty acids; metabolic syndrome; cardiovascular disease; omega-6 and omega-3 fatty acid ratio; cardiometabolic parameters; obese individuals omega-3 fatty acids; metabolic syndrome; cardiovascular disease; omega-6 and omega-3 fatty acid ratio; cardiometabolic parameters; obese individuals
Show Figures

Figure 1

MDPI and ACS Style

Lee, J.-W.; Kim, Y.; Hyun, T.; Song, S.; Yang, W.; Kim, Y.-S.; You, H.-S.; Chang, Y.-C.; Shin, S.-H.; Kang, H.-T. Beneficial Effects of a Specially Designed Home Meal Replacement on Cardiometabolic Parameters in Individuals with Obesity: Preliminary Results of a Randomized Controlled Clinical Trial. Nutrients 2021, 13, 2171. https://doi.org/10.3390/nu13072171

AMA Style

Lee J-W, Kim Y, Hyun T, Song S, Yang W, Kim Y-S, You H-S, Chang Y-C, Shin S-H, Kang H-T. Beneficial Effects of a Specially Designed Home Meal Replacement on Cardiometabolic Parameters in Individuals with Obesity: Preliminary Results of a Randomized Controlled Clinical Trial. Nutrients. 2021; 13(7):2171. https://doi.org/10.3390/nu13072171

Chicago/Turabian Style

Lee, Jae-Woo, Yonghwan Kim, Taisun Hyun, Seunghye Song, Woojung Yang, Ye-Seul Kim, Hyo-Sun You, Young-Chang Chang, Seung-Ho Shin, and Hee-Taik Kang. 2021. "Beneficial Effects of a Specially Designed Home Meal Replacement on Cardiometabolic Parameters in Individuals with Obesity: Preliminary Results of a Randomized Controlled Clinical Trial" Nutrients 13, no. 7: 2171. https://doi.org/10.3390/nu13072171

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop