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Article

Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome

1
Department of Family Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan
2
Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 100, Taiwan
3
Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan
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Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan
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Joint Biobank, Office of Human Research, Taipei Medical University, Taipei 110, Taiwan
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Department of Medical Research, Taipei Medical University Hospital, Taipei 110, Taiwan
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Office of Information Technology, Taipei Medical University, Taipei 110, Taiwan
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Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan
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Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan
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School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan
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Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this study.
Academic Editor: Carla Mastrorilli
Nutrients 2021, 13(5), 1559; https://doi.org/10.3390/nu13051559
Received: 16 March 2021 / Revised: 24 April 2021 / Accepted: 27 April 2021 / Published: 5 May 2021
(This article belongs to the Special Issue Nutrition, Diet and Food Allergy)
Maternal nutrition intake during pregnancy may affect the mother-to-child transmission of bacteria, resulting in gut microflora changes in the offspring, with long-term health consequences in later life. Longitudinal human studies are lacking, as only a small amount of studies showing the effect of nutrition intake during pregnancy on the gut microbiome of infants have been performed, and these studies have been mainly conducted on animals. This pilot study explores the effects of high or low fruit and vegetable gestational intake on the infant microbiome. We enrolled pregnant women with a complete 3-day dietary record and received postpartum follow-up. The 16S rRNA gene sequence was used to characterize the infant gut microbiome at 2 months (n = 39). Principal coordinate analysis ordination revealed that the infant gut microbiome clustered differently for high and low maternal fruit and vegetable consumption (p < 0.001). The linear discriminant analysis effect size and feature selection identified 6 and 17 taxa from both the high and low fruit and vegetable consumption groups. Among the 23 abundant taxa, we observed that six maternal intake nutrients were associated with nine taxa (e.g., Erysipelatoclostridium, Isobaculum, Lachnospiraceae, Betaproteobacteria, Burkholderiaceae, Sutterella, Clostridia, Clostridiales, and Lachnoclostridium). The amount of gestational fruit and vegetable consumption is associated with distinct changes in the infant gut microbiome at 2 months of age. Therefore, strategies involving increased fruit and vegetable consumption during pregnancy should be employed for modifying the gut microbiome early in life. View Full-Text
Keywords: nutrients; infant gut microbiome; pregnancy; vegetables; fruits nutrients; infant gut microbiome; pregnancy; vegetables; fruits
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MDPI and ACS Style

Fan, H.-Y.; Tung, Y.-T.; Yang, Y.-C.S.H.; Hsu, J.B.; Lee, C.-Y.; Chang, T.-H.; Su, E.C.-Y.; Hsieh, R.-H.; Chen, Y.-C. Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome. Nutrients 2021, 13, 1559. https://doi.org/10.3390/nu13051559

AMA Style

Fan H-Y, Tung Y-T, Yang Y-CSH, Hsu JB, Lee C-Y, Chang T-H, Su EC-Y, Hsieh R-H, Chen Y-C. Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome. Nutrients. 2021; 13(5):1559. https://doi.org/10.3390/nu13051559

Chicago/Turabian Style

Fan, Hsien-Yu, Yu-Tang Tung, Yu-Chen S.H. Yang, Justin B. Hsu, Cheng-Yang Lee, Tzu-Hao Chang, Emily C.-Y. Su, Rong-Hong Hsieh, and Yang-Ching Chen. 2021. "Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome" Nutrients 13, no. 5: 1559. https://doi.org/10.3390/nu13051559

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