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Article

Coconut Oil Supplementation Does Not Affect Blood Pressure Variability and Oxidative Stress: A Placebo-Controlled Clinical Study in Stage-1 Hypertensive Patients

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Health Sciences Center, Department of Physiology and Pathology, Federal University of Paraiba, Joao Pessoa 58051-900, Brazil
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Biotechnology Center, Federal University of Paraiba, Joao Pessoa 58051-900, Brazil
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Health Sciences Center, Department of Nutrition, Federal University of Paraiba, Joao Pessoa 58051-900, Brazil
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Medical Sciences Center, Federal University of Paraiba, Joao Pessoa 58051-900, Brazil
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Health Sciences Center, Department of Physical Education, Federal University of Paraiba, Joao Pessoa 58051-900, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Silvio Buscemi
Nutrients 2021, 13(3), 798; https://doi.org/10.3390/nu13030798
Received: 20 November 2020 / Revised: 16 February 2021 / Accepted: 24 February 2021 / Published: 28 February 2021
(This article belongs to the Special Issue Diet, Obesity, Type 2 Diabetes and Hypertension)
Exploring an alternative to improve the clinical management of hypertension, we tested the hypothesis that food supplementation with coconut oil (EVCO), alone or combined with aerobic exercise training, could exert an antihypertensive effect (primary outcome) in patients with stage 1 hypertension. Forty-five hypertensive volunteers of both genders participated in a placebo-controlled clinical trial. The volunteers were submitted to 24-hour ambulatory blood pressure monitoring, analysis of blood pressure variability (BPV), measurement of serum malondialdehyde (MDA) and nutritional assessment. Results indicate that EVCO consumption had no adverse effects. The supplementation did not increase the caloric intake compared with placebo, and the dietary constituents were similar between groups, except for the saturated fats, especially lauric acid. The analysis of blood pressure indicated absence of antihypertensive effect of EVCO alone or combined with physical training. Furthermore, no effects on blood pressure variability and oxidative stress were observed in the supplemented hypertensive patients. Thus, despite the results observed in pre-clinical studies, the current clinical study did not provide evidence to support the use of coconut oil as an adjuvant in the management of hypertension in humans. View Full-Text
Keywords: nutritional approach; cardiovascular system; hypertension; coconut oil nutritional approach; cardiovascular system; hypertension; coconut oil
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MDPI and ACS Style

Júnior, F.A.O.; Ruiz, C.R.; de Oliveira, Y.; Barros, M.A.V.; Silva, A.S.; Santos, M.S.B.; Martins, V.J.B.; Balarini, C.M.; Braga, V.A. Coconut Oil Supplementation Does Not Affect Blood Pressure Variability and Oxidative Stress: A Placebo-Controlled Clinical Study in Stage-1 Hypertensive Patients. Nutrients 2021, 13, 798. https://doi.org/10.3390/nu13030798

AMA Style

Júnior FAO, Ruiz CR, de Oliveira Y, Barros MAV, Silva AS, Santos MSB, Martins VJB, Balarini CM, Braga VA. Coconut Oil Supplementation Does Not Affect Blood Pressure Variability and Oxidative Stress: A Placebo-Controlled Clinical Study in Stage-1 Hypertensive Patients. Nutrients. 2021; 13(3):798. https://doi.org/10.3390/nu13030798

Chicago/Turabian Style

Júnior, Francisco A.O., Clara R. Ruiz, Yohanna de Oliveira, Marco A.V. Barros, Alexandre S. Silva, Maria S.B. Santos, Vinícius J.B. Martins, Camille M. Balarini, and Valdir A. Braga 2021. "Coconut Oil Supplementation Does Not Affect Blood Pressure Variability and Oxidative Stress: A Placebo-Controlled Clinical Study in Stage-1 Hypertensive Patients" Nutrients 13, no. 3: 798. https://doi.org/10.3390/nu13030798

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