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Open AccessCommentary

Vitamin D Supplementation to Prevent COVID-19 Infections and Deaths—Accumulating Evidence from Epidemiological and Intervention Studies Calls for Immediate Action

1
German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, 69120 Heidelberg, Germany
2
Network Aging Research, Heidelberg University, 69115 Heidelberg, Germany
Academic Editor: Spyridon Karras
Nutrients 2021, 13(2), 411; https://doi.org/10.3390/nu13020411
Received: 28 December 2020 / Revised: 23 January 2021 / Accepted: 24 January 2021 / Published: 28 January 2021
The COVID-19 pandemic poses an unprecedented threat to human health, health care systems, public life, and economy around the globe. The repertoire of effective therapies for severe courses of the disease has remained limited. A large proportion of the world population suffers from vitamin D insufficiency or deficiency, with prevalence being particularly high among the COVID-19 high-risk populations. Vitamin D supplementation has been suggested as a potential option to prevent COVID-19 infections, severe courses, and deaths from the disease, but is not widely practiced. This article provides an up-to-date summary of recent epidemiological and intervention studies on a possible role of vitamin D supplementation for preventing severe COVID-19 cases and deaths. Despite limitations and remaining uncertainties, accumulating evidence strongly supports widespread vitamin D supplementation, in particular of high-risk populations, as well as high-dose supplementation of those infected. Given the dynamics of the COVID-19 pandemic, the benefit–risk ratio of such supplementation calls for immediate action even before results of ongoing large-scale randomized trials become available. View Full-Text
Keywords: COVID-19; mortality; prevention; supplementation; vitamin D COVID-19; mortality; prevention; supplementation; vitamin D
MDPI and ACS Style

Brenner, H. Vitamin D Supplementation to Prevent COVID-19 Infections and Deaths—Accumulating Evidence from Epidemiological and Intervention Studies Calls for Immediate Action. Nutrients 2021, 13, 411. https://doi.org/10.3390/nu13020411

AMA Style

Brenner H. Vitamin D Supplementation to Prevent COVID-19 Infections and Deaths—Accumulating Evidence from Epidemiological and Intervention Studies Calls for Immediate Action. Nutrients. 2021; 13(2):411. https://doi.org/10.3390/nu13020411

Chicago/Turabian Style

Brenner, Hermann. 2021. "Vitamin D Supplementation to Prevent COVID-19 Infections and Deaths—Accumulating Evidence from Epidemiological and Intervention Studies Calls for Immediate Action" Nutrients 13, no. 2: 411. https://doi.org/10.3390/nu13020411

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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