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Open AccessArticle

A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation

1
Department of Pharmacology, School of Pharmacy, University of Seville, 41012 Seville, Spain
2
Department of Organic Chemistry, School of Chemistry, University of Seville, 41012 Seville, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Lindsay Brown
Nutrients 2021, 13(2), 311; https://doi.org/10.3390/nu13020311
Received: 9 December 2020 / Revised: 14 January 2021 / Accepted: 15 January 2021 / Published: 22 January 2021
(This article belongs to the Special Issue Health Benefits of Edible Oils)
Oleuropein (OL), an olive tree secoiridoid and its peracetylated derivate (Per-OL) have exhibited several beneficial effects on LPS-stimulated macrophages and murine experimental systemic lupus erythematosus (SLE). This study was designed to evaluate dietary Per-OL in comparison with OL supplementation effects on collagen-induced arthritis (CIA) murine model. Three-weeks-old DBA-1/J male mice were fed from weaning with a standard commercial diet or experimental enriched-diets in 0.05 % (w/w) OL, 0.05% and 0.025% Per-OL. After six weeks of pre-treatment, arthritis was induced by bovine collagen type II by tail base injection (day 0) and on day 21, mice received a booster injection. Mice were sacrificed 42 days after the first immunization. Both Per-OL and OL diets significantly prevented histological damage and arthritic score development, although no statistically significant differences were observed between both compounds. Also, serum collagen oligomeric matrix protein (COMP), metalloprotease (MMP)-3 and pro-inflammatory cytokines levels were ameliorated in paws from secoiridoids fed animals. Mitogen-activated protein kinases (MAPK)s and nuclear transcription factor-kappa-B (NF-κB) activations were drastically down-regulated whereas nuclear factor E2-related factor 2 (Nrf2) and heme-oxygenase-1 (HO-1) protein expressions were up-regulated in those mice fed with OL and Per-OL diets. We conclude that both Per-OL and its parent compound, OL, supplements might provide a basis for developing a new dietary strategy for the prevention of rheumatoid arthritis. View Full-Text
Keywords: arthritis; CIA; inflammation; MAPK; NF-κB; Nrf2/HO1; oleuropein arthritis; CIA; inflammation; MAPK; NF-κB; Nrf2/HO1; oleuropein
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MDPI and ACS Style

Castejón, M.L.; Alarcón-de-la-Lastra, C.; Rosillo, M.Á.; Montoya, T.; Fernández-Bolaños, J.G.; González-Benjumea, A.; Sánchez-Hidalgo, M. A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation. Nutrients 2021, 13, 311. https://doi.org/10.3390/nu13020311

AMA Style

Castejón ML, Alarcón-de-la-Lastra C, Rosillo MÁ, Montoya T, Fernández-Bolaños JG, González-Benjumea A, Sánchez-Hidalgo M. A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation. Nutrients. 2021; 13(2):311. https://doi.org/10.3390/nu13020311

Chicago/Turabian Style

Castejón, María L.; Alarcón-de-la-Lastra, Catalina; Rosillo, María Á.; Montoya, Tatiana; Fernández-Bolaños, Jose G.; González-Benjumea, Alejandro; Sánchez-Hidalgo, Marina. 2021. "A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation" Nutrients 13, no. 2: 311. https://doi.org/10.3390/nu13020311

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