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Volume 13
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Article

Raphani Semen (Raphanus sativus L.) Ameliorates Alcoholic Fatty Liver Disease by Regulating De Novo Lipogenesis

by
Woo Yong Park
1,2,†,
Gahee Song
1,2,†,
Joon Hak Noh
3,†,
Taegon Kim
3,†,
Jae Jin Kim
3,†,
Seokbeom Hong
4,
Jinbong Park
2,3 and
Jae-Young Um
1,2,3,4,*
1
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
2
Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
3
College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
4
Department of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2021, 13(12), 4448; https://doi.org/10.3390/nu13124448
Submission received: 14 October 2021 / Revised: 25 November 2021 / Accepted: 7 December 2021 / Published: 13 December 2021
(This article belongs to the Section Phytochemicals and Human Health)
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Abstract

In this study, we investigated the pharmacological effect of a water extract of Raphani Semen (RSWE) on alcoholic fatty liver disease (AFLD) using ethanol-induced AFLD mice (the NIAAA model) and palmitic acid (PA)-induced steatosis HepG2 cells. An RSWE supplement improved serum and hepatic triglyceride (TG) levels of AFLD mice, as well as their liver histological structure. To explore the molecular action of RSWE in the improvement of AFLD, we investigated the effect of RSWE on four major pathways for lipid homeostasis in the liver: free fatty acid transport, lipogenesis, lipolysis, and β-oxidation. Importantly, RSWE decreased the mRNA expression of de novo lipogenesis-related genes, such as Srebf1, Cebpa, Pparg, and Lpin1, as well as the protein levels of these factors, in the liver of AFLD mice. That these actions of RSWE affect lipogenesis was confirmed using PA-induced steatosis HepG2 cells. Overall, our findings suggest that RSWE has the potential for improvement of AFLD by inhibiting de novo lipogenesis.
Keywords: AFLD; Raphani Semen; lipogenesis; SREBF1; Lpin1 AFLD; Raphani Semen; lipogenesis; SREBF1; Lpin1

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MDPI and ACS Style

Park, W.Y.; Song, G.; Noh, J.H.; Kim, T.; Kim, J.J.; Hong, S.; Park, J.; Um, J.-Y. Raphani Semen (Raphanus sativus L.) Ameliorates Alcoholic Fatty Liver Disease by Regulating De Novo Lipogenesis. Nutrients 2021, 13, 4448. https://doi.org/10.3390/nu13124448

AMA Style

Park WY, Song G, Noh JH, Kim T, Kim JJ, Hong S, Park J, Um J-Y. Raphani Semen (Raphanus sativus L.) Ameliorates Alcoholic Fatty Liver Disease by Regulating De Novo Lipogenesis. Nutrients. 2021; 13(12):4448. https://doi.org/10.3390/nu13124448

Chicago/Turabian Style

Park, Woo Yong, Gahee Song, Joon Hak Noh, Taegon Kim, Jae Jin Kim, Seokbeom Hong, Jinbong Park, and Jae-Young Um. 2021. "Raphani Semen (Raphanus sativus L.) Ameliorates Alcoholic Fatty Liver Disease by Regulating De Novo Lipogenesis" Nutrients 13, no. 12: 4448. https://doi.org/10.3390/nu13124448

APA Style

Park, W. Y., Song, G., Noh, J. H., Kim, T., Kim, J. J., Hong, S., Park, J., & Um, J.-Y. (2021). Raphani Semen (Raphanus sativus L.) Ameliorates Alcoholic Fatty Liver Disease by Regulating De Novo Lipogenesis. Nutrients, 13(12), 4448. https://doi.org/10.3390/nu13124448

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