Next Article in Journal
High Maternal Omega-3 Supplementation Dysregulates Body Weight and Leptin in Newborn Male and Female Rats: Implications for Hypothalamic Developmental Programming
Next Article in Special Issue
Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study
Previous Article in Journal
Effects of a Synbiotic Formula on Functional Bowel Disorders and Gut Microbiota Profile during Long-Term Home Enteral Nutrition (LTHEN): A Pilot Study
Previous Article in Special Issue
Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation
Open AccessReview

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

1
Food Bioscience Group, Department of Bioactivity and Food Analysis, Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), Calle Nicolás Cabrera, 9, 28049 Madrid, Spain
2
High Performance Research Group in Physiopathology and Pharmacology of the Digestive System NeuGut-URJC, Department of Basic Health Sciences, Faculty of Health Sciences, Campus de Alcorcón, Universidad Rey Juan Carlos (URJC), Avda. de Atenas s/n, 28022 Madrid, Spain
3
Associated Unit to Institute of Medicinal Chemistry (Unidad Asociada I+D+i del Instituto de Química Médica, IQM), Spanish National Research Council (Consejo Superior de Investigaciones Científicas, CSIC), 28006 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 88; https://doi.org/10.3390/nu13010088
Received: 9 December 2020 / Revised: 23 December 2020 / Accepted: 25 December 2020 / Published: 29 December 2020
(This article belongs to the Special Issue Coffee and Caffeine Consumption for Human Health)
Coffee is one of the most popular beverages consumed worldwide. Roasted coffee is a complex mixture of thousands of bioactive compounds, and some of them have numerous potential health-promoting properties that have been extensively studied in the cardiovascular and central nervous systems, with relatively much less attention given to other body systems, such as the gastrointestinal tract and its particular connection with the brain, known as the brain–gut axis. This narrative review provides an overview of the effect of coffee brew; its by-products; and its components on the gastrointestinal mucosa (mainly involved in permeability, secretion, and proliferation), the neural and non-neural components of the gut wall responsible for its motor function, and the brain–gut axis. Despite in vitro, in vivo, and epidemiological studies having shown that coffee may exert multiple effects on the digestive tract, including antioxidant, anti-inflammatory, and antiproliferative effects on the mucosa, and pro-motility effects on the external muscle layers, much is still surprisingly unknown. Further studies are needed to understand the mechanisms of action of certain health-promoting properties of coffee on the gastrointestinal tract and to transfer this knowledge to the industry to develop functional foods to improve the gastrointestinal and brain–gut axis health. View Full-Text
Keywords: brain–gut axis; caffeine; coffee; coffee by-products; dietary fiber; enteric; gastrointestinal; melanoidins; mucosa; myenteric brain–gut axis; caffeine; coffee; coffee by-products; dietary fiber; enteric; gastrointestinal; melanoidins; mucosa; myenteric
Show Figures

Graphical abstract

MDPI and ACS Style

Iriondo-DeHond, A.; Uranga, J.A.; del Castillo, M.D.; Abalo, R. Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis. Nutrients 2021, 13, 88. https://doi.org/10.3390/nu13010088

AMA Style

Iriondo-DeHond A, Uranga JA, del Castillo MD, Abalo R. Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis. Nutrients. 2021; 13(1):88. https://doi.org/10.3390/nu13010088

Chicago/Turabian Style

Iriondo-DeHond, Amaia; Uranga, José A.; del Castillo, Maria D.; Abalo, Raquel. 2021. "Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis" Nutrients 13, no. 1: 88. https://doi.org/10.3390/nu13010088

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop