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Open AccessArticle

Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast

1
Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zurich, 8092 Zurich, Switzerland
2
VMMT Research, 6950 Tesserete, Switzerland
3
Department of Health, Swiss Distance University of Applied Sciences (Fernfachhochschule Schweiz—FFHS), 3900 Brig, Switzerland
4
Centre Interlude Bien-Être, 1873 Val d’Illiez, Switzerland
5
Fondazione Hospice Ticino, 6900 Lugano, Switzerland
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 255; https://doi.org/10.3390/nu13010255
Received: 21 December 2020 / Revised: 13 January 2021 / Accepted: 14 January 2021 / Published: 17 January 2021
Fasting is becoming an increasingly popular practice. Nevertheless, its clinical benefits and possible inconveniences remain limitedly evaluated. We observed the effects of a seven-day fast conducted in a non-medical center located in the Swiss Alps. Clinical parameters were measured on the first and last day of fasting (D1 and D7), and two months later (D60). Among the 40 participants, blood analyses were done on 25 persons with an increased metabolic risk, with the primary goal of assessing the lasting effect on low-density lipoprotein (LDL) cholesterol. By comparing D60 with D1, high-density lipoprotein cholesterol (HDL) (+0.15 mmol/L) and insulin-like growth factor-1 (IGF-1) (+2.05 mmol/L) increased (both p < 0.009), all other blood parameters (LDL, glucose, total cholesterol, triglycerides, C-reactive protein (CRP)) did not change; weight (−0.97 kg) and hearth rate (−7.31 min−1) decreased (both p < 0.006). By comparing D7 with D1, total cholesterol (+0.44 mmol/L), triglycerides (+0.37 mmol/L) and CRP (+3.37 mg/L) increased (all p < 0.02). The lack of LDL variation at D60 may be due to the low metabolic risk level of the participants. The increase of total cholesterol, triglycerides and CRP at D7 warrants studies to understand whether such fluctuations represent a stress reaction to the fasting state, which may vary in different fasting types. View Full-Text
Keywords: fasting; periodic fasting; lipid profile; LDL; HDL; triglycerides; CRP; IGF-1; body composition fasting; periodic fasting; lipid profile; LDL; HDL; triglycerides; CRP; IGF-1; body composition
MDPI and ACS Style

Galetti, V.; Brnic, M.; Lotin, B.; Frigeri, M. Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast. Nutrients 2021, 13, 255. https://doi.org/10.3390/nu13010255

AMA Style

Galetti V, Brnic M, Lotin B, Frigeri M. Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast. Nutrients. 2021; 13(1):255. https://doi.org/10.3390/nu13010255

Chicago/Turabian Style

Galetti, Valeria; Brnic, Marica; Lotin, Benjamin; Frigeri, Mauro. 2021. "Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast" Nutrients 13, no. 1: 255. https://doi.org/10.3390/nu13010255

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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