Next Article in Journal
A Phase IIb Randomized Controlled Trial Investigating the Effects of Tocotrienol-Rich Vitamin E on Diabetic Kidney Disease
Next Article in Special Issue
The Potential Properties of Natural Compounds in Cardiac Stem Cell Activation: Their Role in Myocardial Regeneration
Previous Article in Journal
Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast
Review

Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review

1
Department of Health Sciences, Institute of Research for Food Safety & Health, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy
2
Cardiology Clinical Academic Group, St George’s Hospitals NHS Trust University of London, London SW17 0QT, UK
3
Department of Cardiology, IRCCS San Raffaele Pisana, 00166 Rome, Italy
4
Department of Cardiology, Charité–Universitätsmedizin Berlin, 10117 Berlin, Germany
5
Faculty of Medicine, Belgrade University, 11000 Belgrade, Serbia
6
Department of Experimental and Applied Medicine, Institute of Cardiology, University of Brescia, 25121 Brescia, Italy
7
Department of Diagnostic Imaging and Interventional Radiology, Policlinico Tor Vergata, 00199 Rome, Italy
8
Department of Experimental Medicine, University of Rome “Tor Vergata”, 00199 Rome, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 257; https://doi.org/10.3390/nu13010257
Received: 11 November 2020 / Revised: 25 December 2020 / Accepted: 13 January 2021 / Published: 17 January 2021
(This article belongs to the Special Issue Nutraceutical Supplements in Heart Failure)
There is evidence demonstrating that heart failure (HF) occurs in 1–2% of the global population and is often accompanied by comorbidities which contribute to increasing the prevalence of the disease, the rate of hospitalization and the mortality. Although recent advances in both pharmacological and non-pharmacological approaches have led to a significant improvement in clinical outcomes in patients affected by HF, residual unmet needs remain, mostly related to the occurrence of poorly defined strategies in the early stages of myocardial dysfunction. Nutritional support in patients developing HF and nutraceutical supplementation have recently been shown to possibly contribute to protection of the failing myocardium, although their place in the treatment of HF requires further assessment, in order to find better therapeutic solutions. In this context, the Optimal Nutraceutical Supplementation in Heart Failure (ONUS-HF) working group aimed to assess the optimal nutraceutical approach to HF in the early phases of the disease, in order to counteract selected pathways that are imbalanced in the failing myocardium. In particular, we reviewed several of the most relevant pathophysiological and molecular changes occurring during the early stages of myocardial dysfunction. These include mitochondrial and sarcoplasmic reticulum stress, insufficient nitric oxide (NO) release, impaired cardiac stem cell mobilization and an imbalanced regulation of metalloproteinases. Moreover, we reviewed the potential of the nutraceutical supplementation of several natural products, such as coenzyme Q10 (CoQ10), a grape seed extract, Olea Europea L.-related antioxidants, a sodium–glucose cotransporter (SGLT2) inhibitor-rich apple extract and a bergamot polyphenolic fraction, in addition to their support in cardiomyocyte protection, in HF. Such an approach should contribute to optimising the use of nutraceuticals in HF, and the effect needs to be confirmed by means of more targeted clinical trials exploring the efficacy and safety of these compounds. View Full-Text
Keywords: heart failure; dysfunctional cardiomyocytes; patho-physiological mechanisms; oxidative stress; nutraceuticals heart failure; dysfunctional cardiomyocytes; patho-physiological mechanisms; oxidative stress; nutraceuticals
Show Figures

Figure 1

MDPI and ACS Style

Mollace, V.; Rosano, G.M.C.; Anker, S.D.; Coats, A.J.S.; Seferovic, P.; Mollace, R.; Tavernese, A.; Gliozzi, M.; Musolino, V.; Carresi, C.; Maiuolo, J.; Macrì, R.; Bosco, F.; Chiocchi, M.; Romeo, F.; Metra, M.; Volterrani, M. Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review. Nutrients 2021, 13, 257. https://doi.org/10.3390/nu13010257

AMA Style

Mollace V, Rosano GMC, Anker SD, Coats AJS, Seferovic P, Mollace R, Tavernese A, Gliozzi M, Musolino V, Carresi C, Maiuolo J, Macrì R, Bosco F, Chiocchi M, Romeo F, Metra M, Volterrani M. Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review. Nutrients. 2021; 13(1):257. https://doi.org/10.3390/nu13010257

Chicago/Turabian Style

Mollace, Vincenzo, Giuseppe M.C. Rosano, Stefan D. Anker, Andrew J.S. Coats, Petar Seferovic, Rocco Mollace, Annamaria Tavernese, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Jessica Maiuolo, Roberta Macrì, Francesca Bosco, Marcello Chiocchi, Francesco Romeo, Marco Metra, and Maurizio Volterrani. 2021. "Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review" Nutrients 13, no. 1: 257. https://doi.org/10.3390/nu13010257

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop