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Article

Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study

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Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia
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Faculty of Health, Deakin University, Geelong, VIC 3217, Australia
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Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, VIC 3168, Australia
4
Metabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2804; https://doi.org/10.3390/nu12092804
Received: 21 August 2020 / Revised: 9 September 2020 / Accepted: 10 September 2020 / Published: 13 September 2020
(This article belongs to the Section Clinical Nutrition)
This is a follow-up of our previous postprandial study and it focused on the plasma lipidomic responses to 30 days of krill oil (KO) versus fish oil (FO) supplementations in healthy women. Eleven women (aged 18–50 years) consumed KO or FO for 30 days in a randomized, cross-over study, with at least a four-week washout period between supplementations. The daily supplements provided 1.27 g/day of long-chain (LC) omega-3 polyunsaturated fatty acids (PUFA) from KO (containing 0.76 g eicosapentaenoic acid (EPA), 0.42 g docosahexaenoic acid (DHA)) and 1.44 g/day from FO (containing 0.79 g EPA, 0.47 g DHA). Fasting plasma samples at days 0, 15, and 30 were analyzed using gas chromatography and liquid chromatography electrospray ionisation-tandem mass spectrometry. KO resulted in a significantly greater relative area under the curve (relAUC) for plasma EPA after 30 days. Lipidomic analysis showed that 26 of 43 lipid molecular species had a significantly greater relAUC in the KO group, while 17/43 showed a significantly lower relAUC compared with the FO group. More than 38% of the lipids species which increased more following KO contained omega-3 PUFA, while where FO was greater than KO, only 12% contained omega-3 PUFA. These data show that KO and FO do not have equivalent effects on the plasma lipidome. View Full-Text
Keywords: krill oil; fish oil; plasma lipidomic response; EPA; DHA; phospholipids; phosphatidylcholine; 30-day study; women; lipidome krill oil; fish oil; plasma lipidomic response; EPA; DHA; phospholipids; phosphatidylcholine; 30-day study; women; lipidome
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MDPI and ACS Style

Sung, H.H.; Sinclair, A.J.; Huynh, K.; Smith, A.A.T.; Mellett, N.A.; Meikle, P.J.; Su, X.Q. Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study. Nutrients 2020, 12, 2804. https://doi.org/10.3390/nu12092804

AMA Style

Sung HH, Sinclair AJ, Huynh K, Smith AAT, Mellett NA, Meikle PJ, Su XQ. Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study. Nutrients. 2020; 12(9):2804. https://doi.org/10.3390/nu12092804

Chicago/Turabian Style

Sung, Hyunsin H., Andrew J. Sinclair, Kevin Huynh, Adam A.T. Smith, Natalie A. Mellett, Peter J. Meikle, and Xiao Q. Su. 2020. "Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study" Nutrients 12, no. 9: 2804. https://doi.org/10.3390/nu12092804

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