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Open AccessArticle

Ergogenic Effect of BCAAs and L-Alanine Supplementation: Proof-of-Concept Study in a Murine Model of Physiological Exercise

1
Section of Pharmacology, Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Orabona 4—Campus, 70125 Bari, Italy
2
Research & Early Development, Dompé farmaceutici S.p.A., Via Campo di Pile, s.n.c., 67100 L’Aquila, Italy
*
Authors to whom correspondence should be addressed.
These two authors contributed equally to this work.
Nutrients 2020, 12(8), 2295; https://doi.org/10.3390/nu12082295
Received: 24 June 2020 / Revised: 23 July 2020 / Accepted: 27 July 2020 / Published: 30 July 2020
(This article belongs to the Section Sports Nutrition)
Background: Branched-chain amino acids (BCAAs: leucine, isoleucine, valine) account for 35% of skeletal muscle essential amino acids (AAs). As such, they must be provided in the diet to support peptide synthesis and inhibit protein breakdown. Although substantial evidence has been collected about the potential usefulness of BCAAs in supporting muscle function and structure, dietary supplements containing BCAAs alone may not be effective in controlling muscle protein turnover, due to the rate-limiting bioavailability of other AAs involved in BCAAs metabolism. Methods: We aimed to evaluate the in vivo/ex vivo effects of a 4-week treatment with an oral formulation containing BCAAs alone (2:1:1) on muscle function, structure, and metabolism in a murine model of physiological exercise, which was compared to three modified formulations combining BCAAs with increasing concentrations of L-Alanine (ALA), an AA controlling BCAAs catabolism. Results: A preliminary pharmacokinetic study confirmed the ability of ALA to boost up BCAAs bioavailability. After 4 weeks, mix 2 (BCAAs + 2ALA) had the best protective effect on mice force and fatigability, as well as on muscle morphology and metabolic indices. Conclusion: Our study corroborates the use of BCAAs + ALA to support muscle health during physiological exercise, underlining how the relative BCAAs/ALA ratio is important to control BCAAs distribution. View Full-Text
Keywords: dietary supplements; branched-chain amino acids; L-Alanine; exercise; resistance to fatigue; preclinical study; murine model dietary supplements; branched-chain amino acids; L-Alanine; exercise; resistance to fatigue; preclinical study; murine model
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MDPI and ACS Style

Mantuano, P.; Bianchini, G.; Cappellari, O.; Boccanegra, B.; Conte, E.; Sanarica, F.; Mele, A.; Camerino, G.M.; Brandolini, L.; Allegretti, M.; De Bellis, M.; Aramini, A.; De Luca, A. Ergogenic Effect of BCAAs and L-Alanine Supplementation: Proof-of-Concept Study in a Murine Model of Physiological Exercise. Nutrients 2020, 12, 2295. https://doi.org/10.3390/nu12082295

AMA Style

Mantuano P, Bianchini G, Cappellari O, Boccanegra B, Conte E, Sanarica F, Mele A, Camerino GM, Brandolini L, Allegretti M, De Bellis M, Aramini A, De Luca A. Ergogenic Effect of BCAAs and L-Alanine Supplementation: Proof-of-Concept Study in a Murine Model of Physiological Exercise. Nutrients. 2020; 12(8):2295. https://doi.org/10.3390/nu12082295

Chicago/Turabian Style

Mantuano, Paola; Bianchini, Gianluca; Cappellari, Ornella; Boccanegra, Brigida; Conte, Elena; Sanarica, Francesca; Mele, Antonietta; Camerino, Giulia M.; Brandolini, Laura; Allegretti, Marcello; De Bellis, Michela; Aramini, Andrea; De Luca, Annamaria. 2020. "Ergogenic Effect of BCAAs and L-Alanine Supplementation: Proof-of-Concept Study in a Murine Model of Physiological Exercise" Nutrients 12, no. 8: 2295. https://doi.org/10.3390/nu12082295

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