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Article

Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans

1
INQUIS Clinical Research, Ltd. (formerly GI Labs), Toronto, ON M5C 2N8, Canada
2
VTT Technical Research Centre of Finland Ltd., 1000 Espoo, Finland
3
School of Nutrition Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada
4
DSM Nutritional Products Ltd., R&D Human Nutrition and Health, 4002 Basel, Switzerland
5
Department of Surgery, Division of Visceral and Transplantation Surgery, University Hospital Zürich, 8091 Zürich, Switzerland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2275; https://doi.org/10.3390/nu12082275
Received: 24 June 2020 / Revised: 21 July 2020 / Accepted: 27 July 2020 / Published: 29 July 2020
(This article belongs to the Special Issue Beta-Glucan in Foods and Health Benefits)
To see if the molecular weight (MW) and viscosity of oat β-glucan (OBG) when taken before eating determine its effect on postprandial glycemic responses (PPRG), healthy overnight-fasted subjects (n = 16) were studied on eight separate occasions. Subjects consumed 200 mL water alone (Control) or with 4 g OBG varying in MW and viscosity followed, 2–3 min later, by 113 g white-bread. Blood was taken fasting and at 15, 30, 45, 60, 90, and 120 min after starting to eat. None of the OBG treatments differed significantly from the Control for the a-priori primary endpoint of glucose peak-rise or secondary endpoint of incremental area-under-the-curve (iAUC) over 0–120 min. However, significant differences from the Control were seen for glucose iAUC over 0–45 min and time to peak (TTP) glucose. Lower log(MW) and log(viscosity) were associated with higher iAUC 0–45 (p < 0.001) and shorter TTP (p < 0.001). We conclude that when 4 g OBG is taken as a preload, reducing MW does not affect glucose peak rise or iAUC0-120, but rather accelerates the rise in blood glucose and reduces the time it takes glucose to reach the peak. However, this is based on post-hoc calculation of iAUC0-45 and TTP and needs to be confirmed in a subsequent study. View Full-Text
Keywords: humans; oat β-glucan; acute glycemic response; dietary fiber; preload; carbohydrates humans; oat β-glucan; acute glycemic response; dietary fiber; preload; carbohydrates
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MDPI and ACS Style

Wolever, T.M.S.; Mattila, O.; Rosa-Sibakov, N.; Tosh, S.M.; Jenkins, A.L.; Ezatagha, A.; Duss, R.; Steinert, R.E. Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans. Nutrients 2020, 12, 2275. https://doi.org/10.3390/nu12082275

AMA Style

Wolever TMS, Mattila O, Rosa-Sibakov N, Tosh SM, Jenkins AL, Ezatagha A, Duss R, Steinert RE. Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans. Nutrients. 2020; 12(8):2275. https://doi.org/10.3390/nu12082275

Chicago/Turabian Style

Wolever, Thomas M.S.; Mattila, Outi; Rosa-Sibakov, Natalia; Tosh, Susan M.; Jenkins, Alexandra L.; Ezatagha, Adish; Duss, Ruedi; Steinert, Robert E. 2020. "Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans" Nutrients 12, no. 8: 2275. https://doi.org/10.3390/nu12082275

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