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Gastroprotective and Healing Effects of Polygonum cuspidatum Root on Experimentally Induced Gastric Ulcers in Rats

Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
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Nutrients 2020, 12(8), 2241; https://doi.org/10.3390/nu12082241
Received: 16 June 2020 / Revised: 20 July 2020 / Accepted: 23 July 2020 / Published: 27 July 2020
(This article belongs to the Section Phytochemicals and Human Health)
Polygonum cuspidatum is widely used as food and medicine in Korea, China, and Japan. Its major bioactive components, resveratrol and emodin, reportedly protect against gastric lesions. We therefore aimed to investigate: (1) the gastroprotective effects of P. cuspidatum roots in hydrochloric acid/ethanol (HCl/EtOH)- and indomethacin-induced acute gastric ulcer rat models; (2) the healing effects in an acetic acid-induced ulcer model; and (3) potential mechanisms by measuring gastric acid secretion-related parameters in a pyloric ligation-induced ulcer model, and by measuring antioxidant enzyme and prostaglandin E2 levels in the gastric tissue of HCl/EtOH-treated rats. Oral administration of P. cuspidatum extract (PCE) at doses of 100 and 300 mg/kg significantly decreased HCl/EtOH- and indomethacin-induced gastric lesions. PCE at 300 mg/kg significantly reduced gastric lesions in acetic acid-induced ulcers. PCE increased superoxide dismutase (SOD) activity and glutathione (GSH) and prostaglandin E2 levels in gastric tissue, whereas it did not alter gastric acid secretion-related parameters. Our findings indicate that PCE has gastroprotective effects against HCl/EtOH and non-steroidal anti-inflammatory drugs (NSAIDs) and promotes healing of acetic acid-induced ulcers. These gastric mucosal protection and ulcer healing effects are associated with antioxidant effects and the augmentation of prostaglandin E2 and suggest that P. cuspidatum might be a promising preventive and therapeutic agent for treating gastric ulcers. View Full-Text
Keywords: Polygonum cuspidatum; gastric ulcer; gastritis; gastric acid; antioxidant; prostaglandin E2 Polygonum cuspidatum; gastric ulcer; gastritis; gastric acid; antioxidant; prostaglandin E2
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MDPI and ACS Style

Kim, Y.-S.; Nam, Y.; Song, J.; Kim, H. Gastroprotective and Healing Effects of Polygonum cuspidatum Root on Experimentally Induced Gastric Ulcers in Rats. Nutrients 2020, 12, 2241. https://doi.org/10.3390/nu12082241

AMA Style

Kim Y-S, Nam Y, Song J, Kim H. Gastroprotective and Healing Effects of Polygonum cuspidatum Root on Experimentally Induced Gastric Ulcers in Rats. Nutrients. 2020; 12(8):2241. https://doi.org/10.3390/nu12082241

Chicago/Turabian Style

Kim, Young-Sik, YunSeol Nam, Jungbin Song, and Hocheol Kim. 2020. "Gastroprotective and Healing Effects of Polygonum cuspidatum Root on Experimentally Induced Gastric Ulcers in Rats" Nutrients 12, no. 8: 2241. https://doi.org/10.3390/nu12082241

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