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Open AccessArticle

Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation

1
Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden
2
Department of Infectious Diseases, Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden
3
Department of Food Technology, Engineering and Nutrition, Lund University, 22100 Lund, Sweden
4
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide SA 5001, Australia
5
The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2172; https://doi.org/10.3390/nu12082172
Received: 24 May 2020 / Revised: 10 July 2020 / Accepted: 18 July 2020 / Published: 22 July 2020
(This article belongs to the Special Issue Nutrition for Cancer Survivors)
Patients undergoing radiotherapy to treat pelvic-organ cancer are commonly advised to follow a restricted fiber diet. However, reducing dietary fiber may promote gastrointestinal inflammation, eventually leading to deteriorated intestinal health. The goal of this study was to evaluate the influence of dietary fiber on radiation-induced inflammation. C57BL/6J male mice were fed a High-oat bran diet (15% fiber) or a No-fiber diet (0% fiber) and were either irradiated (32 Gy delivered in four fractions) to the colorectal region or only sedated (controls). The dietary intervention started at 2 weeks before irradiation and lasted for 1, 6, and 18 weeks after irradiation, at which time points mice were sacrificed and their serum samples were assayed for 23 cytokines and chemokines. Our analyses show that irradiation increased the serum cytokine levels at all the time points analyzed. The No-fiber irradiated mice had significantly higher levels of pro-inflammatory cytokines than the High-oat irradiated mice at all time points. The results indicate that a fiber-rich oat bran diet reduces the intensity of radiation-induced inflammation, both at an early and late stage. Based on the results, it seems that the advice to follow a low-fiber diet during radiotherapy may increase the risk of decreased intestinal health in cancer survivors. View Full-Text
Keywords: pelvic radiotherapy; radiation-induced inflammation; serum cytokines; dietary fiber; oat bran pelvic radiotherapy; radiation-induced inflammation; serum cytokines; dietary fiber; oat bran
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MDPI and ACS Style

Patel, P.; Malipatlolla, D.K.; Devarakonda, S.; Bull, C.; Rascón, A.; Nyman, M.; Stringer, A.; Tremaroli, V.; Steineck, G.; Sjöberg, F. Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation. Nutrients 2020, 12, 2172. https://doi.org/10.3390/nu12082172

AMA Style

Patel P, Malipatlolla DK, Devarakonda S, Bull C, Rascón A, Nyman M, Stringer A, Tremaroli V, Steineck G, Sjöberg F. Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation. Nutrients. 2020; 12(8):2172. https://doi.org/10.3390/nu12082172

Chicago/Turabian Style

Patel, Piyush; Malipatlolla, Dilip K.; Devarakonda, Sravani; Bull, Cecilia; Rascón, Ana; Nyman, Margareta; Stringer, Andrea; Tremaroli, Valentina; Steineck, Gunnar; Sjöberg, Fei. 2020. "Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation" Nutrients 12, no. 8: 2172. https://doi.org/10.3390/nu12082172

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