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The Action of JAK/STAT3 and BMP/HJV/SMAD Signaling Pathways on Hepcidin Suppression by Tucum-do-Cerrado in a Normal and Iron-Enriched Diets

1
Postgraduate Program in Human Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília 70910-900, Brazil
2
Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília 70910-900, Brazil
3
Institute of Physics, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília 70910-900, Brazil
*
Author to whom correspondence should be addressed.
Current address: Campus Reitor Edgard Santos, Biological and Health Sciences Center, Universidade Federal do Oeste da Bahia, Barreiras 47810-059, Brazil.
Nutrients 2020, 12(5), 1515; https://doi.org/10.3390/nu12051515
Received: 5 April 2020 / Revised: 13 May 2020 / Accepted: 15 May 2020 / Published: 22 May 2020
(This article belongs to the Section Nutrition and Metabolism)
The Brazilian savanna fruit, tucum-do-cerrado (Bactris setosa Mart.) reduces hepatic hepcidin levels. Therefore, we investigated the effect of tucum-do-cerrado on the TfR/HFE and/or BMP/HJV/SMAD and JAK/STAT pathways, in normal and excess iron conditions. Rats were treated with: control diet (CT); control diet +15% tucum-do-cerrado (Tuc); iron-enriched diet (+Fe); or iron-enriched diet +15% tucum-do-cerrado (Tuc+Fe). Tucum-do-cerrado (Tuc) decreased hepatic Hamp and Hjv mRNA levels but did not alter Bmp6, Smad7, Tfr1, and Hfe mRNA levels; pSMAD1/5/8 and pSTAT3 protein levels; labile iron pool (LIP); and inflammatory biomarkers, compared to the CT group. The iron-enriched diet increased Hamp mRNA levels, as well as pSMAD1/5/8 and pSTAT3 protein levels, while no difference was observed in Hjv, Bmp6, Smad7, Tfr1, and Hfe mRNA levels and LIP compared to the CT group. The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group. Therefore, the inhibition of hepatic hepcidin by tucum-do-cerrado consumption may involve the downregulation of intestinal Dmt1 and hepatic Hjv expression and deacetylation mediated by SIRT1 by a mechanism that is independent of tissue iron content. However, in excess iron conditions, the modulation of hepatic hepcidin expression by tucum-do-cerrado seems to be partially mediated by the inflammatory signaling pathway, as well as involves the chelating activity of tucum-do-cerrado. View Full-Text
Keywords: tucum-do-cerrado; hepcidin; pSMAD1/5/8; pSTAT3; iron tucum-do-cerrado; hepcidin; pSMAD1/5/8; pSTAT3; iron
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    Doi: doi:10.3390/nu9111243
MDPI and ACS Style

Arruda, S.F.; Ramos, L.V.; Barbosa, J.L.A.; Hankins, N.A.C.; Rodrigues, P.A.M.; da Cunha, M.S.B. The Action of JAK/STAT3 and BMP/HJV/SMAD Signaling Pathways on Hepcidin Suppression by Tucum-do-Cerrado in a Normal and Iron-Enriched Diets. Nutrients 2020, 12, 1515.

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