Next Article in Journal
Effect of a Combination of Citrus Flavones and Flavanones and Olive Polyphenols for the Reduction of Cardiovascular Disease Risk: An Exploratory Randomized, Double-Blind, Placebo-Controlled Study in Healthy Subjects
Previous Article in Journal
The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?
Open AccessArticle

Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study

1
Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
2
Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
3
Department of Mathematics and Statistics, Boston University College of Arts and Sciences, Boston, MA 02215, USA
4
Division of Cardiovascular Medicine Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
5
Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA
6
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
7
Framingham Heart Study, Framingham, MA 01702, USA
8
Nutrition Epidemiology and Data Science, Tufts University Friedman School of Nutrition Science and Policy, Boston, MA 02111, USA
9
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
10
Nutrition Epidemiology, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
11
Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
12
Center for Computing and Data Sciences, Boston University, Boston, MA 02215, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1476; https://doi.org/10.3390/nu12051476
Received: 16 April 2020 / Revised: 12 May 2020 / Accepted: 16 May 2020 / Published: 19 May 2020
(This article belongs to the Section Nutrigenetics and Nutrigenomics)
Data on proteomic and metabolomic signatures of healthy dietary patterns are limited. We evaluated the cross-sectional association of serum proteomic and metabolomic markers with three dietary patterns: the Alternative Healthy Eating Index (AHEI), the Dietary Approaches to Stop Hypertension (DASH) diet; and a Mediterranean-style (MDS) diet. We examined participants from the Framingham Offspring Study (mean age; 55 years; 52% women) who had complete proteomic (n = 1713) and metabolomic (n = 2284) data; using food frequency questionnaires to derive dietary pattern indices. Proteins and metabolites were quantified using the SomaScan platform and liquid chromatography/tandem mass spectrometry; respectively. We used multivariable-adjusted linear regression models to relate each dietary pattern index (independent variables) to each proteomic and metabolomic marker (dependent variables). Of the 1373 proteins; 103 were associated with at least one dietary pattern (48 with AHEI; 83 with DASH; and 8 with MDS; all false discovery rate [FDR] ≤ 0.05). We identified unique associations between dietary patterns and proteins (17 with AHEI; 52 with DASH; and 3 with MDS; all FDR ≤ 0.05). Significant proteins enriched biological pathways involved in cellular metabolism/proliferation and immune response/inflammation. Of the 216 metabolites; 65 were associated with at least one dietary pattern (38 with AHEI; 43 with DASH; and 50 with MDS; all FDR ≤ 0.05). All three dietary patterns were associated with a common signature of 24 metabolites (63% lipids). Proteins and metabolites associated with dietary patterns may help characterize intermediate phenotypes that provide insights into the molecular mechanisms mediating diet-related disease. Our findings warrant replication in independent populations View Full-Text
Keywords: dietary patterns; diet quality; proteomic; metabolomic; biomarker dietary patterns; diet quality; proteomic; metabolomic; biomarker
Show Figures

Figure 1

MDPI and ACS Style

Walker, M.E.; Song, R.J.; Xu, X.; Gerszten, R.E.; Ngo, D.; Clish, C.B.; Corlin, L.; Ma, J.; Xanthakis, V.; Jacques, P.F.; Vasan, R.S. Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study. Nutrients 2020, 12, 1476.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop