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Open AccessArticle

Effect of a Combination of Citrus Flavones and Flavanones and Olive Polyphenols for the Reduction of Cardiovascular Disease Risk: An Exploratory Randomized, Double-Blind, Placebo-Controlled Study in Healthy Subjects

1
Health Sciences Department, Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, E-30107 Murcia, Spain
2
Health Sciences Ph.D. Program, Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, E-30107 Murcia, Spain
3
Research and Development Department, Nutrafur iff-Health, E-30820 Murcia, Spain
4
Unidad de Enfermedades Infecciosas, Hospital General Universitario Reina Sofia, E-30003 Murcia, Spain
5
Food Technology & Nutrition Department, Universidad Católica San Antonio de Murcia (UCAM), E-30107 Murcia, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1475; https://doi.org/10.3390/nu12051475
Received: 13 April 2020 / Revised: 12 May 2020 / Accepted: 16 May 2020 / Published: 19 May 2020
(This article belongs to the Special Issue Diet, Nutrition and Chronic Degenerative Diseases)
A single-center, randomized, double-blind controlled trial was conducted to assess the efficacy of a food supplement based on a combination of grapefruit, bitter orange, and olive extracts administered for eight weeks (n = 51) versus placebo (n = 45) on reduction of cardiovascular risk in healthy volunteers. Study variables included flow-mediated vasodilation (FMD), blood pressure (BP), lipid profile, thrombotic status, oxidative stress biomarkers, inflammation-related biomarkers, anthropometric variables, quality of life, and physical activity. The per-protocol data set was analyzed. In the active product group, there were statistically significant within-group differences at eight weeks as compared with baseline in FMD, systolic and diastolic BP, total cholesterol, LDL-C, LDL-oxidase, oxidized/reduced glutathione ratio, protein carbonyl, and IL-6. Significant between-group differences in these variables were also found. Significant changes in anthropometric variables and quality of life were not observed in the study groups. Changes in the level of physical activity were not recorded. Treatment with the active product was well tolerated. All these findings, taken together, support a beneficial effect of supplementation with a mixture of grapefruit, bitter orange fruits, and olive leaf extracts on underlying mechanisms that may interact each other to decrease the cardiovascular risk in healthy people. View Full-Text
Keywords: bitter orange; cardiovascular risk; citrus flavonoids; endothelial function; grapefruit; olive; polyphenols; secoiridoids bitter orange; cardiovascular risk; citrus flavonoids; endothelial function; grapefruit; olive; polyphenols; secoiridoids
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Sánchez Macarro, M.; Martínez Rodríguez, J.P.; Bernal Morell, E.; Pérez-Piñero, S.; Victoria-Montesinos, D.; García-Muñoz, A.M.; Cánovas García, F.; Castillo Sánchez, J.; López-Román, F.J. Effect of a Combination of Citrus Flavones and Flavanones and Olive Polyphenols for the Reduction of Cardiovascular Disease Risk: An Exploratory Randomized, Double-Blind, Placebo-Controlled Study in Healthy Subjects. Nutrients 2020, 12, 1475.

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