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The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?

1
Microbiology and Mycology Program, ICBM, Faculty of Medicine, University of Chile, Santiago 8320000, Chile
2
Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8320000, Chile
3
Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7830490, Chile
4
Millennium Nucleus in the Biology of Intestinal Microbiota, Santiago 7830490, Chile
5
Department of Molecular Diagnosis, LACE Laboratories, Córdoba X5000, Argentina
6
Department of Biochemistry, AIIMS, Bhubaneswar 751019, India
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1474; https://doi.org/10.3390/nu12051474
Received: 14 April 2020 / Revised: 7 May 2020 / Accepted: 14 May 2020 / Published: 19 May 2020
(This article belongs to the Special Issue The Link between Diet, Gut Microbes and Health)
The gut microbiota is emerging as a promising target for the management or prevention of inflammatory and metabolic disorders in humans. Many of the current research efforts are focused on the identification of specific microbial signatures, more particularly for those associated with obesity, type 2 diabetes, and cardiovascular diseases. Some studies have described that the gut microbiota of obese animals and humans exhibits a higher Firmicutes/Bacteroidetes ratio compared with normal-weight individuals, proposing this ratio as an eventual biomarker. Accordingly, the Firmicutes/Bacteroidetes ratio is frequently cited in the scientific literature as a hallmark of obesity. The aim of the present review was to discuss the validity of this potential marker, based on the great amount of contradictory results reported in the literature. Such discrepancies might be explained by the existence of interpretative bias generated by methodological differences in sample processing and DNA sequence analysis, or by the generally poor characterization of the recruited subjects and, more particularly, the lack of consideration of lifestyle-associated factors known to affect microbiota composition and/or diversity. For these reasons, it is currently difficult to associate the Firmicutes/Bacteroidetes ratio with a determined health status and more specifically to consider it as a hallmark of obesity. View Full-Text
Keywords: Microbiota; gut; obesity; dysbiosis; Firmicutes; Bacteroidetes; marker Microbiota; gut; obesity; dysbiosis; Firmicutes; Bacteroidetes; marker
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Magne, F.; Gotteland, M.; Gauthier, L.; Zazueta, A.; Pesoa, S.; Navarrete, P.; Balamurugan, R. The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients? Nutrients 2020, 12, 1474.

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