Next Article in Journal
Evaluating Nutrient-Based Indices against Food- and Diet-Based Indices to Assess the Health Potential of Foods: How Does the Australian Health Star Rating System Perform after Five Years?
Next Article in Special Issue
Myoprotective Whole Foods, Muscle Health and Sarcopenia: A Systematic Review of Observational and Intervention Studies in Older Adults
Previous Article in Journal
Higher Cardiorespiratory Fitness Levels May Attenuate the Detrimental Association between Weight Status, Metabolic Phenotype and C-Reactive Protein in Adolescents—A Multi-Cohort Study
Previous Article in Special Issue
A Mediterranean Diet Is Positively Associated with Bone and Muscle Health in a Non-Mediterranean Region in 25,450 Men and Women from EPIC-Norfolk
Review

Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis

1
Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK
2
School of Health Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1457; https://doi.org/10.3390/nu12051457
Received: 12 March 2020 / Revised: 29 April 2020 / Accepted: 6 May 2020 / Published: 18 May 2020
(This article belongs to the Special Issue Diet, Lifestyle and Healthy Ageing)
Observational research suggests that micronutrients may be protective for sarcopenia, a key health issue during ageing, potentially via effects on hormone synthesis and metabolism. We aimed to carry out a systematic review of RCTs investigating effects of increasing dietary or supplemental micronutrient intake on sex hormones and IGF-1 in individuals aged 45 years or older. We searched MEDLINE, EMBASE and Cochrane databases for RCTs reporting the effects of different micronutrients (vitamins A, C, D, or E; carotenoids; iron; copper; zinc; magnesium; selenium; and potassium) on sex hormones or IGF-1. Of the 26 RCTs identified, nine examined effects of vitamin D, nine of multi-nutrients, four of carotenoids, two of selenium, one of zinc, and one of vitamin E. For IGF-1 increasing vitamin D (MD: −0.53 nmol/L, 95% CI: −1.58, 0.52), multi-nutrients (MD: 0.60 nmol/L, 95% CI −1.12 to 2.33) and carotenoids (MD −1.32 nmol/L; 95% CI −2.76 to 0.11) had no significant effect on circulating concentrations. No significant effects on sex hormones of other micronutrients were found, but data were very limited. All trials had significant methodological limitations making effects of micronutrient supplementation on sex hormones unclear. Further high quality RCTs with physiological doses of micronutrients in people with low baseline intakes or circulating concentrations, using robust methodology, are required to assess effects of supplementation adequately. View Full-Text
Keywords: micronutrients; sarcopenia; sex hormones; insulin-like growth factor 1; meta-analysis; randomized controlled trials micronutrients; sarcopenia; sex hormones; insulin-like growth factor 1; meta-analysis; randomized controlled trials
Show Figures

Figure 1

MDPI and ACS Style

Janjuha, R.; Bunn, D.; Hayhoe, R.; Hooper, L.; Abdelhamid, A.; Mahmood, S.; Hayden-Case, J.; Appleyard, W.; Morris, S.; Welch, A. Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis. Nutrients 2020, 12, 1457. https://doi.org/10.3390/nu12051457

AMA Style

Janjuha R, Bunn D, Hayhoe R, Hooper L, Abdelhamid A, Mahmood S, Hayden-Case J, Appleyard W, Morris S, Welch A. Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis. Nutrients. 2020; 12(5):1457. https://doi.org/10.3390/nu12051457

Chicago/Turabian Style

Janjuha, Ryan, Diane Bunn, Richard Hayhoe, Lee Hooper, Asmaa Abdelhamid, Shaan Mahmood, Joseph Hayden-Case, Will Appleyard, Sophie Morris, and Ailsa Welch. 2020. "Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis" Nutrients 12, no. 5: 1457. https://doi.org/10.3390/nu12051457

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop