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Open AccessArticle

Dietary Protein Intake during Pregnancy Is Not Associated with Offspring Insulin Sensitivity during the First Two Years of Life

by 1,2,3, 1,4, 1,2,3,5,*,† and 1,3,*,†
1
Arkansas Children’s Nutrition Center, Little Rock, AR 72202, USA
2
Arkansas Children’s Research Institute, Little Rock, AR 72202, USA
3
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
4
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
5
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
*
Authors to whom correspondence should be addressed.
Co-Senior Authors.
Nutrients 2020, 12(5), 1338; https://doi.org/10.3390/nu12051338
Received: 25 March 2020 / Revised: 23 April 2020 / Accepted: 2 May 2020 / Published: 8 May 2020
Literature describing a relationship between dietary protein intake during pregnancy and offspring insulin resistance are equivocal perhaps because of the lapse between maternal and offspring measurements (~9–40 years). Thus, we evaluated protein intake in healthy women [n = 182, mean ± SD; body mass index (BMI): 26.2 ± 4.2 kg/m2] in early pregnancy (8.4 ± 1.6 weeks, EP), late pregnancy (30.1 ± 0.4 weeks, LP), and averaged throughout pregnancy, and determined the relationship between protein intake and offspring homeostatic model assessment of insulin resistance (HOMA2-IR) at 12 (12mo) and 24 (24mo) months. EP protein (g·kg−1·day−1) did not associate with HOMA2-IR at 12mo (β = 0.153, p = 0.429) or 24mo (β = −0.349, p = 0.098). LP protein did not associate with HOMA2-IR at 12mo (β = 0.023, p = 0.916) or 24mo (β = −0.442, p = 0.085). Finally, average protein did not associate with HOMA2-IR at 12mo (β = 0.711, p = 0.05) or 24mo (β = −0.445, p = 0.294). Results remained unchanged after adjusting for plant protein intake quartiles during pregnancy, maternal BMI, and offspring sex and body fat percentage. Additionally, these relationships did not change after quartile analysis of average protein intake, even after considering offspring fasting time and HOMA2-IR outliers, and maternal under-reporters of energy intake. Protein intake during pregnancy is not associated with indirect measurements of insulin sensitivity in offspring during the first two years of life. View Full-Text
Keywords: pregnancy; offspring; protein; insulin resistance; insulin sensitivity; HOMA-IR; obesity; plant protein; glucose; insulin pregnancy; offspring; protein; insulin resistance; insulin sensitivity; HOMA-IR; obesity; plant protein; glucose; insulin
MDPI and ACS Style

Allman, B.R.; Williams, D.K.; Børsheim, E.; Andres, A. Dietary Protein Intake during Pregnancy Is Not Associated with Offspring Insulin Sensitivity during the First Two Years of Life. Nutrients 2020, 12, 1338. https://doi.org/10.3390/nu12051338

AMA Style

Allman BR, Williams DK, Børsheim E, Andres A. Dietary Protein Intake during Pregnancy Is Not Associated with Offspring Insulin Sensitivity during the First Two Years of Life. Nutrients. 2020; 12(5):1338. https://doi.org/10.3390/nu12051338

Chicago/Turabian Style

Allman, Brittany R.; Williams, D. K.; Børsheim, Elisabet; Andres, Aline. 2020. "Dietary Protein Intake during Pregnancy Is Not Associated with Offspring Insulin Sensitivity during the First Two Years of Life" Nutrients 12, no. 5: 1338. https://doi.org/10.3390/nu12051338

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