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Article

Interaction between Coffee Drinking and TRIB1 rs17321515 Single Nucleotide Polymorphism on Coronary Heart Disease in a Taiwanese Population

1
Institute of Medicine, Chung Shan Medical University, Taichung City 40201, Taiwan
2
Department of Cardiovascular Surgery, Asia University Hospital, Taichung 41354, Taiwan
3
Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan
4
Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan
5
Department of Physical Education, Fu Jen Catholic University, New Taipei 24205, Taiwan
6
Research and Development Center for Physical Education, Health, and Information Technology, Fu Jen Catholic University, New Taipei 24205, Taiwan
7
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
8
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1301; https://doi.org/10.3390/nu12051301
Received: 5 March 2020 / Revised: 27 April 2020 / Accepted: 27 April 2020 / Published: 2 May 2020
(This article belongs to the Special Issue Coffee and Caffeine Consumption for Human Health)
A complex interplay of several genetic and lifestyle factors influence coronary heart disease (CHD). We determined the interaction between coffee consumption and the tribbles pseudokinase 1 (TRIB1) rs17321515 variant on coronary heart disease (CHD). Data on CHD were obtained from the National Health Insurance Research Database (NHIRD) while genotype data were collected from the Taiwan Biobank (TWB) Database. From the linked electronic health record data, 1116 individuals were identified with CHD while 7853 were control individuals. Coffee consumption was associated with a lower risk of CHD. The multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) was 0.84 (0.72–0.99). Association of CHD with the TRIB1 rs17321515 variant was not significant. The OR (95% CI) was 1.01 (0.72–0.99). There was an interaction between TRIB1 rs17321515 and coffee consumption on CHD risk (p for interaction = 0.0330). After stratification by rs17321515 genotypes, coffee drinking remained significantly associated with a lower risk of CHD only among participants with GG genotype (OR, 0.62; 95% CI, 0.45–0.85). In conclusion, consumption of coffee was significantly associated with a decreased risk of CHD among Taiwanese adults with the TRIB1 GG genotype. View Full-Text
Keywords: coffee drinking; TRIB1; rs17321515; CHD; Taiwan Biobank coffee drinking; TRIB1; rs17321515; CHD; Taiwan Biobank
MDPI and ACS Style

Liu, Y.-T.; Tantoh, D.M.; Wang, L.; Nfor, O.N.; Hsu, S.-Y.; Ho, C.-C.; Lung, C.-C.; Chang, H.-R.; Liaw, Y.-P. Interaction between Coffee Drinking and TRIB1 rs17321515 Single Nucleotide Polymorphism on Coronary Heart Disease in a Taiwanese Population. Nutrients 2020, 12, 1301. https://doi.org/10.3390/nu12051301

AMA Style

Liu Y-T, Tantoh DM, Wang L, Nfor ON, Hsu S-Y, Ho C-C, Lung C-C, Chang H-R, Liaw Y-P. Interaction between Coffee Drinking and TRIB1 rs17321515 Single Nucleotide Polymorphism on Coronary Heart Disease in a Taiwanese Population. Nutrients. 2020; 12(5):1301. https://doi.org/10.3390/nu12051301

Chicago/Turabian Style

Liu, Yin-Tso, Disline M. Tantoh, Lee Wang, Oswald N. Nfor, Shu-Yi Hsu, Chien-Chang Ho, Chia-Chi Lung, Horng-Rong Chang, and Yung-Po Liaw. 2020. "Interaction between Coffee Drinking and TRIB1 rs17321515 Single Nucleotide Polymorphism on Coronary Heart Disease in a Taiwanese Population" Nutrients 12, no. 5: 1301. https://doi.org/10.3390/nu12051301

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