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Article

Walnut Oil Alleviates Intestinal Inflammation and Restores Intestinal Barrier Function in Mice

1
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland
2
Department of Family Medicine and Community Nursing, Medical University of Lublin, 20-081 Lublin, Poland
3
Department of Pathology, Faculty of Medicine, Medical University of Lodz, 92-213 Lodz, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1302; https://doi.org/10.3390/nu12051302
Received: 28 March 2020 / Revised: 19 April 2020 / Accepted: 30 April 2020 / Published: 2 May 2020
(This article belongs to the Section Nutrition and Metabolism)
Ulcerative colitis belongs to inflammatory bowel diseases, which is a group of chronic disorders of the gastrointestinal tract. It is a debilitating condition with a wide range of symptoms including rectal bleeding, diarrhea, and visceral pain. Current dietary habits often lead to imbalance in n-6/n-3 polyunsaturated fatty acids (PUFA) in favor of n-6 PUFA. Recent data showed the potential anti-inflammatory advantage of n-3 PUFA. Walnut oil (WO) is rich in those fatty acids and mainly consists of linoleic and linolenic acids that may act via free fatty acids receptors (FFARs). We assessed the anti-inflammatory effect of WO in the mouse model of dextran sulfate sodium (DSS)-induced colitis. Moreover, we examined changes in the expression of tight junction proteins (TJ), pro-inflammatory cytokines, and FFAR proteins in the inflamed mouse colon. WO improves the damage score in inflamed tissue, significantly restoring ion transport and colonic wall permeability. Inflammation caused changes in TJ, FFAR, and pro-inflammatory gene proteins expression, which WO was able to partially reverse. WO has anti-inflammatory properties; however, its exact mechanism of action remains unclear. This stems from the pleiotropic effects of n-3 PUFA ligands associated with receptor distribution and targeted signaling pathways. View Full-Text
Keywords: inflammatory bowel disease; ion transport; colon permeability; tight junction; free fatty acid receptors inflammatory bowel disease; ion transport; colon permeability; tight junction; free fatty acid receptors
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MDPI and ACS Style

Bartoszek, A.; Makaro, A.; Bartoszek, A.; Kordek, R.; Fichna, J.; Salaga, M. Walnut Oil Alleviates Intestinal Inflammation and Restores Intestinal Barrier Function in Mice. Nutrients 2020, 12, 1302. https://doi.org/10.3390/nu12051302

AMA Style

Bartoszek A, Makaro A, Bartoszek A, Kordek R, Fichna J, Salaga M. Walnut Oil Alleviates Intestinal Inflammation and Restores Intestinal Barrier Function in Mice. Nutrients. 2020; 12(5):1302. https://doi.org/10.3390/nu12051302

Chicago/Turabian Style

Bartoszek, Adrian; Makaro, Adam; Bartoszek, Agnieszka; Kordek, Radzisław; Fichna, Jakub; Salaga, Maciej. 2020. "Walnut Oil Alleviates Intestinal Inflammation and Restores Intestinal Barrier Function in Mice" Nutrients 12, no. 5: 1302. https://doi.org/10.3390/nu12051302

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