Next Article in Journal
Walnut Oil Alleviates Intestinal Inflammation and Restores Intestinal Barrier Function in Mice
Next Article in Special Issue
Effects of 120 g/h of Carbohydrates Intake during a Mountain Marathon on Exercise-Induced Muscle Damage in Elite Runners
Previous Article in Journal
Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
Previous Article in Special Issue
Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise
Open AccessReview

Effects of Arginine Supplementation on Athletic Performance Based on Energy Metabolism: A Systematic Review and Meta-Analysis

Glut4Science, Physiology, Nutrition and Sport, 01004 Vitoria-Gasteiz, Spain
Department of Nursing and Physiotherapy, University of León, 24071 León, Spain
Institute of Biomedicine (IBIOMED), Physiotherapy Department, University of Leon, Researcher of Basque Country University, Campus de Vegazana, 24071 Leon, Spain
Department of Biochemistry Molecular Biology and Physiology, Faculty of Health Sciences, University of Valladolid, 42004 Soria, Spain
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1300;
Received: 12 March 2020 / Revised: 12 April 2020 / Accepted: 24 April 2020 / Published: 2 May 2020
(This article belongs to the Special Issue Nutrition and Muscle Recovery)
Nitric oxide related ergogenic aids such as arginine (Arg) have shown to impact positively on sport performance through several physiological and metabolic mechanisms. However, research results have shown to be controversial. The great differences regarding required metabolic pathways and physiological demands between aerobic and anaerobic sport disciplines could be the reasons. The aim of this systematic review and meta-analysis was to evaluate the effects of Arg supplementation on aerobic (≤VO2max) and anaerobic (>VO2max) performance. Likewise, to show the effective dose and timing of this supplementation. A structured search was carried out in accordance with PRISMA® (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and PICOS guidelines in PubMed/MEDLINE, Web of Science (WOS), and Scopus databases from inception to January 2020. Eighteen studies were included which compare Arg supplementation with placebo in an identical situation and testing its effects on aerobic and anaerobic performance tests. Trials analyzing supplementation with other supplements were removed and there was not athlete’s level, gender, ethnicity, or age filters. The performed meta-analysis included 15 studies and random effects model and pooled standardized mean differences (SMD) were used according to Hedges’ g. Results revealed that Arg supplementation could improve aerobic (SMD, 0.84; 95% CI, 0.12 to 1.56; magnitude of SMD (MSMD), large; I2, 89%; p = 0.02) and anaerobic (SMD, 0.24; 95% CI, 0.05 to 0.43; MSMD, small; I2, 0%; p = 0.01) performance tests. In conclusion, acute Arg supplementation protocols to improve aerobic and anaerobic performance should be adjusted to 0.15 g/kg of body weight ingested between 60–90 min before. Moreover, chronic Arg supplementation should include 1.5–2 g/day for 4–7 weeks in order to improve aerobic performance, and 10–12 g/day for 8 weeks to enhance anaerobic performance. View Full-Text
Keywords: aminoacids; ergogenic aids; physical performance; nitric oxide; aerobic; anaerobic aminoacids; ergogenic aids; physical performance; nitric oxide; aerobic; anaerobic
Show Figures

Figure 1

MDPI and ACS Style

Viribay, A.; Burgos, J.; Fernández-Landa, J.; Seco-Calvo, J.; Mielgo-Ayuso, J. Effects of Arginine Supplementation on Athletic Performance Based on Energy Metabolism: A Systematic Review and Meta-Analysis. Nutrients 2020, 12, 1300.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop