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Article

Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise

1
Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017 Las Palmas de Gran Canaria, Spain
2
Nektium Pharma, Agüimes, 35118 Las Palmas de Gran Canaria, Spain
3
Complejo Hospitalario Universitario Insular-Materno Infantil de Las Palmas de Gran Canaria, Clinical Genetics Unit, 35016 Las Palmas de Gran Canaria, Spain
4
Department of Physical Performance, Norwegian School of Sport Sciences, 0806 Oslo, Norway
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 614; https://doi.org/10.3390/nu12030614
Received: 14 January 2020 / Revised: 20 February 2020 / Accepted: 21 February 2020 / Published: 26 February 2020
(This article belongs to the Special Issue Nutrition and Muscle Recovery)
Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 h thereafter for 24 h, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite® combined with 140 mg of quercetin (double-blind). Although competition times were similar, polyphenol supplementation attenuated the muscle pain felt after the competition (6.8 ± 1.5 and 5.7 ± 2.2 a.u., p = 0.035) and the loss of jumping performance (9.4 ± 11.5 and 3.9 ± 5.2%, p = 0.036; p = 0.034) and mechanical impulse (p = 0.038) 24 h later. The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction p < 0.05). In conclusion, a single dose of 140 mg Zynamite® combined with 140 mg of quercetin, administered one hour before competition, followed by three additional doses every eight hours, attenuates muscle pain and damage, and accelerates the recovery of muscle performance. View Full-Text
Keywords: ergogenic aids; polyphenols; antioxidant supplementation; eccentric exercise; DOMS; EIMD; sports nutrition; inflammation; human subjects; muscle function ergogenic aids; polyphenols; antioxidant supplementation; eccentric exercise; DOMS; EIMD; sports nutrition; inflammation; human subjects; muscle function
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MDPI and ACS Style

Martin-Rincon, M.; Gelabert-Rebato, M.; Galvan-Alvarez, V.; Gallego-Selles, A.; Martinez-Canton, M.; Lopez-Rios, L.; Wiebe, J.C.; Martin-Rodriguez, S.; Arteaga-Ortiz, R.; Dorado, C.; Perez-Regalado, S.; Santana, A.; Morales-Alamo, D.; Calbet, J.A.L. Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise. Nutrients 2020, 12, 614. https://doi.org/10.3390/nu12030614

AMA Style

Martin-Rincon M, Gelabert-Rebato M, Galvan-Alvarez V, Gallego-Selles A, Martinez-Canton M, Lopez-Rios L, Wiebe JC, Martin-Rodriguez S, Arteaga-Ortiz R, Dorado C, Perez-Regalado S, Santana A, Morales-Alamo D, Calbet JAL. Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise. Nutrients. 2020; 12(3):614. https://doi.org/10.3390/nu12030614

Chicago/Turabian Style

Martin-Rincon, Marcos, Miriam Gelabert-Rebato, Victor Galvan-Alvarez, Angel Gallego-Selles, Miriam Martinez-Canton, Laura Lopez-Rios, Julia C. Wiebe, Saul Martin-Rodriguez, Rafael Arteaga-Ortiz, Cecilia Dorado, Sergio Perez-Regalado, Alfredo Santana, David Morales-Alamo, and Jose A.L. Calbet 2020. "Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise" Nutrients 12, no. 3: 614. https://doi.org/10.3390/nu12030614

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