Next Article in Journal
Effects of Shift Work on the Eating Behavior of Police Officers on Patrol
Next Article in Special Issue
Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors
Previous Article in Journal
Exercise-Associated Hyponatremia during the Olympus Marathon Ultra-Endurance Trail Run
Previous Article in Special Issue
Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review
Open AccessArticle

CYP27B1 Gene Polymorphism rs10877012 in Patients Diagnosed with Colorectal Cancer

1
Faculty of Biology and Biotechnology, University of Warmia and Mazury, 10-719 Olsztyn, Poland
2
Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland
3
Department of General Surgery, Faculty of Medical Sciences, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland
4
Independent Public Healthcare Center of Ministry of Internal Affairs and Administration with the Warmia and Mazury Center of Oncology, 10-228 Olsztyn, Poland
5
General and Colorectal Surgery Clinic, University Clinical Hospital of the Military Medical Academy—Central Veterans Hospital, 90-549 Lodz, Poland
6
Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University and Research, 6700 AG Wageningen, The Netherlands
7
Clinical Department of Trauma-Orthopedic Surgery and Spine Surgery of the Provincial Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland
8
Department and Cinic of Orthopaedics and Traumatology, Collegium Medicum, University of Warmia and Mazury, 10-719 Olsztyn, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 998; https://doi.org/10.3390/nu12040998
Received: 29 February 2020 / Revised: 25 March 2020 / Accepted: 1 April 2020 / Published: 3 April 2020
(This article belongs to the Special Issue The Role of Vitamin D in Chronic Diseases)
Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide. Intestinal cells are CYP27B1 gene expression sites and, as a consequence, they are capable of converting pro-vitamin D into the active paracrine and autocrine forms. It was demonstrated that rs10877012 polymorphism in the CYP27B1 gene influenced the circulating vitamin D level. This provided a rationale for determining the role that this polymorphism plays in the risk of developing colon cancer. In this study, we investigated the association of rs10877012 (T/G) polymorphism in the CYP27B1 gene with CRC susceptibility. The study population (n = 325) included CRC patients (n = 106) and healthy controls (n = 219). DNA was extracted from peripheral leukocytes and analyzed for the CYP27B1 polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We found an association between the presence of the T allele at the polymorphic site (odds ratio (OR) = 2.94; 95% CI 1.77–4.86; p < 0.0001) and a decreased CRC incidence. View Full-Text
Keywords: rs10877012; colorectal cancer; vitamin D; single nucleotide polymorphism (SNP); CYP27B1 rs10877012; colorectal cancer; vitamin D; single nucleotide polymorphism (SNP); CYP27B1
Show Figures

Graphical abstract

MDPI and ACS Style

Latacz, M.; Snarska, J.; Kostyra, E.; Wroński, K.; Fiedorowicz, E.; Savelkoul, H.; Jarmołowska, B.; Płomiński, J.; Grzybowski, R.; Cieślińska, A. CYP27B1 Gene Polymorphism rs10877012 in Patients Diagnosed with Colorectal Cancer. Nutrients 2020, 12, 998.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop