Next Article in Journal
Regulatory and Policy-Related Aspects of Calcium Fortification of Foods. Implications for Implementing National Strategies of Calcium Fortification
Next Article in Special Issue
Possible Role of Vitamin D in Celiac Disease Onset
Previous Article in Journal
Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources
Previous Article in Special Issue
CYP27B1 Gene Polymorphism rs10877012 in Patients Diagnosed with Colorectal Cancer
Open AccessReview

Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors

1
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, 97080 Wuerzburg, Germany
2
Department of Clinical Medicine, Bufalini Hospital, 47521 Cesena, Italy
3
Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy
4
UOC of Internal Medicine, AO dei Colli, Monaldi Unit, 80131 Naples, Italy
5
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK
6
Clinica Medica 3, Department of Medicine, DIMED, University of Padova, 35128 Padova, Italy
7
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1021; https://doi.org/10.3390/nu12041021
Received: 3 March 2020 / Revised: 30 March 2020 / Accepted: 3 April 2020 / Published: 8 April 2020
(This article belongs to the Special Issue The Role of Vitamin D in Chronic Diseases)
Patients affected by gastroenteropancreatic–neuroendocrine tumors (GEP–NETs) have an increased risk of developing osteopenia and osteoporosis, as several factors impact on bone metabolism in these patients. In fact, besides the direct effect of bone metastasis, bone health can be affected by hormone hypersecretion (including serotonin, cortisol, and parathyroid hormone-related protein), specific microRNAs, nutritional status (which in turn could be affected by medical and surgical treatments), and vitamin D deficiency. In patients with multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome associated with NET occurrence, bone damage may carry other consequences. Osteoporosis may negatively impact on the quality of life of these patients and can increment the cost of medical care since these patients usually live with their disease for a long time. However, recommendations suggesting screening to assess bone health in GEP–NET patients are missing. The aim of this review is to critically analyze evidence on the mechanisms that could have a potential impact on bone health in patients affected by GEP–NET, focusing on vitamin D and its role in GEP–NET, as well as on factors associated with MEN1 that could have an impact on bone homeostasis. View Full-Text
Keywords: bone; vitamin D; neuroendocrine tumor; osteoporosis; mineral bone density; cortisol; serotonin; miRNA; MEN1; therapy bone; vitamin D; neuroendocrine tumor; osteoporosis; mineral bone density; cortisol; serotonin; miRNA; MEN1; therapy
Show Figures

Figure 1

MDPI and ACS Style

Altieri, B.; Di Dato, C.; Modica, R.; Bottiglieri, F.; Di Sarno, A.; Pittaway, J.F.; Martini, C.; Faggiano, A.; Colao, A., on behalf of NIKE group; Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic Neuroendocrine Tumors. Nutrients 2020, 12, 1021.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop